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Title

The effect of different concentrations of artemin on the formation of α-synuclein s amyloid fibrils

Year: 1396
Publish place:
COI: CBGCONF04_094
Language: EnglishView: 268
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Authors

Narges Marvastizade - Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
Bahareh Dabirmanesh - Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
Reza Hassan-Sajedi - Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
Khosro Khajeh - Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran

Abstract:

Partially folded stages in folding process arise due to a large number of hydrophobic amide groups exposing to solvent and capable of forming interactions between the molecules and leading to the formation of large protein complexes. The accumulation of altered proteins such as alpha-synuclein is a common pathogenic mechanism inseveral neurodegenerative disorders such as Alzheimer s and Parkinson s disease. Chaperones are shown to be critical in the process of protein folding, thus the presence of these molecules like artemin as a molecular chaperone may play an important role in preventing fibril formation process. For this reason α-synuclein was expressed, purified and concentrated using Polyethylene Glycol. Subsequently its fibrillation was examined in the absence and presence of different concentrations ( 0.001, 0.002, 0.004 and 0.016 mg/ml) of artemin, using ThioflavinT Fluorescence and Congo red absorption. Results revealed that 0.002 and 0.004 concentrations had more effect on fibril formation.

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This Paper COI Code is CBGCONF04_094. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

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Marvastizade, Narges and Dabirmanesh, Bahareh and Hassan-Sajedi, Reza and Khajeh, Khosro,1396,The effect of different concentrations of artemin on the formation of α-synuclein s amyloid fibrils,چهارمین کنفرانس بین المللی پژوهشهای کاربردی در علوم شیمی و زیست شناسی,Tehran,https://civilica.com/doc/686201

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Type of center: دانشگاه دولتی
Paper count: 31,795
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