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Development and validation of voltammetric method for the determination of anti breast cancer drug at different electrolytes.

Publish Year: 1396
Type: Conference paper
Language: English
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NRSEC01_024

Index date: 26 February 2018

Development and validation of voltammetric method for the determination of anti breast cancer drug at different electrolytes. abstract

In this work, The electro-oxidative behaviour of tamoxifen (Tam) as an anti breast cancer drug was investigated at different electrolytes such as Britton-Robinson (BR) buffer, H2SO4, HNO3, CH3COOH and H3PO4 by differential-pulse adsorptive anodic stripping (DPAdAS) technique. To investigate the mechanism, we performed chronoamperometry, CV at different scan rates and differential pulse anodic voltammetry (DPAV) on tam-covered glassy carbon electrodes (GCEs). The primary experiments demonstrated that the DPAASV presents a sufficient oxidation peak current at approximately 1.03 V vs Ag/AgCl. Therefore, the effects of different parameters such as electrolytes, deposition potential and deposition time have been studied and optimized. The obtained results shown that the H2SO4 as electrolyte, -1.4 V and 30s are the optimal values, respectively. Then the calibration curve was plotted in the range of 0.5 to 80 μM and the limits of detection (LOD) and quantitation (LOQ) were calculated to be 0.12 and 0.4 μM, respectively. The mean, standard error and relative standard deviation (RSD) for 4 replicates of 15 μM were found to be 15.57 μM, 3% and 4%, respectively. To estimate the application potential of the proposed method, the extraction of Tam from tablets containing 20 mg Tam were investigated and optimized.

Development and validation of voltammetric method for the determination of anti breast cancer drug at different electrolytes. Keywords:

Development and validation of voltammetric method for the determination of anti breast cancer drug at different electrolytes. authors

Z. Deris Falahieh

Department of Chemistry, Student of Analytical Chemistry, Islamic Azad University, Arak Branch, Arak, Iran

M. Jalali

Department of Chemistry, Faculty of Science, Islamic Azad University, Omidiyeh BranchOmidiyeh, Iran

M. Alimoradi

Department of Chemistry, Faculty of Science, Islamic Azad University, Arak Branch, Arak, Iran