Anti-vascular Endothelial Growth Factor Effect of Topical Timolol for Non-center-involving Diabetic Macular Edema
Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
IRAVOMED08_063
تاریخ نمایه سازی: 21 اردیبهشت 1397
Abstract:
Purpose: we aim to evaluate the effect of topical timolol in patients with non-center involving diabetic macular edema.Methods: In this prospective, interventional case series subjects with non-center-involving diabetic macular edema were treated with topical timolol twice daily for at least three months. Macular thickness at thickest point was measured at baseline, one month and three months. Results: Twenty-one eyes of 16 subjects with mean age of 57.09 ±5.98 years (range: 48 to 71) were included. Macular thickness at thickest point was 408.80 ±37.13 (range: 364 to 492) μm, 390.47 ±37.91 μm (range: 307 to 465) and 383.00 ± 30.76 μm (range: 337 to 454)at baseline, one month and three months, respectively. Repeated measure ANOVA revealed that the reduction in macular thickness was significant at one and three months compared with baseline (P=0.005 and P=0.001, respectively).Conclusion: We found topical timolol is effective for reducing non-center-involving diabetic macular edema. This effect may be mediated by its anti-vascular endothelial growth factor activity
Authors
KhMacularalil Ghasemi Falavarjani
Eye Research Center and Department of Ophthalmology, Rassoul Akram Hospital, Iran University of Medical Sciences
Yasaman Hadi
Eye Research Center and Department of Ophthalmology, Rassoul Akram Hospital, Iran University of Medical Sciences
Samira Jafari
Eye Research Center and Department of Ophthalmology, Rassoul Akram Hospital, Iran University of Medical Sciences
Mohammad Mehdi Parvaresh
Eye Research Center and Department of Ophthalmology, Rassoul Akram Hospital, Iran University of Medical Sciences