COMPARISON PREVALENCE OF TOXOPLASMA GONDII IN KIDNEY TRANSPLANTATION REGIMES

Background and Aim:Toxoplasmosis is one of the common worldwide parasitic zoonosis, caused by the protozoan parasite Toxoplasma gondii. This disease in solid organ transplantation is uncommon but causes serious morbidity and mortality. The aim of this study was to determine the prevalence of T. gondii IgG and IgM in kidney transplant patients receiving three regimes Sirolimus (SSR), Cyclosporine A (SCA) and Tacrolimus (TAC) in Kashan.Methods:In this historical cohort study, fifty serum samples were collected from kidney transplant recipient in Beheshti hospital of Kashan during 2014-2015. Enzyme-linked immunosorbent assay (ELISA) was used for detection of T.gondii-IgG and T.gondii-IgM antibodies. Toxoplasma IgG and IgM were negative in all of patients before kidney transplantation. The patients received three drugs regimes including Sirolimus, Cyclosporine A and Tacrolimus plus Micophenlate Mofetil (MMF) and Glucocorticoid (GCC) and followed for mean six years (1-15yrs). SPSS and X2 and Fisher exact tests were used for statistical analysis.Results:T.gondii-IgG antibody was detected in 34.8% of patients receiving SSR+MMF+(GCC), 68.2% of patients receiving SCA+MMF+(GCC) and 60% TAC+MMF+(GCC), respectively (P=0.09). T.gondii-IgM antibody was negative in three groups.Conclusion:According to the results of this study, prevalence of T. gondii was lower in patients receiving Sirolimus plus MMF and GCC compared to other regimes. Therefore applying of Sirolimus regime is better than other medications for toxoplasmosis in kidney recipients.

Keywords:

Toxoplasma gondii , Kidney Transplantation , Sirolimus , Cyclosporine A , Tacrolimus