Antibiotic susceptibility associated with biofilm production in Acinetobacter baumannii isolated from burn wound colonization

Background: Acinetobacter baumannii is consider as an important opportunistic pathogen in hospital whole of the world. Multidrug resistant strains can make very complication in antibiotic therapy and can increase rate of morbidity and mortality in hospitalized patients. Burns patients are in high risk to infect by A. baumannii. This study aims to determine antibiotic susceptibility patterns associated with rate of biofilm production in A. baumannii isolated from burn wound colonization. Methods: In this study 47 isolates of A. baumannii were collected from teaching hospital, Tehran, Iran in 2018. Identifying of bacteria was prepared by conventional biochemical and microbiological methods. Antibiotic susceptibility was done by disc diffusion methods according to CLSI 2018. Tube test was examined for detection the biofilm formation rate in collected strains. Results: All of bacteriawere extensively drug-resistant (XDR) except one isolate. The results of tube test indicated that only 36% of XDR strains are in weak rate of biofilm formation group. Discussion: Presence of XDR strains of A. baumannii is very considerable problem in hospitals. Hence these results are very important for control of nosocomial infection committee in health care systems. On the other hand, this result may indicate that biofilm formation can increase antibiotic resistance next to the other mechanisms of resistance.

Antibiotic susceptibility associated with biofilm production in Acinetobacter baumannii isolated from burn wound colonization Keywords:

A. baumannii , XDR , biofilm