Three-component synthesis of spiro[indole-pyrimidine]one derivatives and evaluation of their antibacterial activity
Publish place: First International Congress of Chemistry and Nanochemistry from Research to Technology
Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
ICCNRT01_165
تاریخ نمایه سازی: 30 دی 1397
Abstract:
Facile and efficient synthesis of spiro[indole-pyrimidine]ones by three-component reactions of phenacylidenetriphenylphosphoranes, oxindoles and thiourea. in presence of chloroacetic acid as catalyst is described. This ecofriendly protocol offers several advantages such as a cost-effective procedure with excellent yield, short reaction time, good functional group tolerance, and broad scope of usable substrates. Antibacterial activity of one of synthesized compounds (4j), minimum bactericidal concentration (MBC) was evaluated against against Gram positive S. aureus and B. subtilis and Gram negative E. coli and P. aeruginosa at different concentration. The results showed that the compounds 4j was shown strong antibacterial activity at concentration 0.05 mg ml-1 against Gram-negative and Gram negative bacteria.
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Authors
Maryam Pourshab
Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, ۴۷۴۱۶- ۹۵۴۴۷, Iran
Sakineh Asghari
Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, ۴۷۴۱۶- ۹۵۴۴۷, Iran.Nano and Biotechnology Research Group, University of Mazandaran, Babolsar, ۴۷۴۱۶-۹۵۴۴۷, Iran
Asieh Khalilpour
Department of Environmental Health Engineering, Faculty of Paramedical Sciences, Babol University of Medical Sciences, Babol, Iran