validated and Novel Chemiluminescence method for Rapid Determination of Clopidogrel

In this article, chemiluminescence (CL) has been used to determine clopidogrel. The method is based on the measurement of the CL intensity in the reaction between Ru(phen)3 2+ and acidic cerium (IV) enhanced by catalytic effect of clopidogrel. The CL intensities was linear over the concentration ranges of 2.0×10-8 to 8.0×10-6 mol L-1. The detection limit (±3) for clopidogrel calculated 1.2×10-8 mol L-1(5.03 ng mL-1 ). The relative standard deviation for 1.0×10-7 mol L-1 clopidogrel was 6.2%. This method successfully applied for the determination of clopidogrel in pharmaceutical formulations. Sampling rate was about 30 samples h-1.

Keywords:

Chemiluminescence , Acidic Ce (IV) , Ru(phen)3 2+ , Clopidogrel.