Synthesis of Aryl Sulfides via Transition-Metal Free Cross-Coupling of Thiols with Hydrazines.

Transition-metal-catalyzed carbon−heteroatom cross-coupling reactions have made a great contribution to the recent growth of organic synthesis. Although the arylsulfides have broad application in the pharmaceutical industry and material science and as intermediates in organic synthesis, the formation of carbon−sulfur bonds hasreceived less attention. Difficulties in C−S bond formation can be attributed to the sulfur species rapidly and irreversibly deactivating the catalyst. So the efficient formation of the C−S bond is a most important aspect of organic chemistry. Many research groups have made great effort to overcome this problem in recent years, and several excellent catalytic systems that used Pd, Cu, Ni, Fe, and other metals as catalysts have been found for C−S bond formation by couplings of aryl halides with thiols or disulfides [1]. Aryl Sulfides are also becoming more prevalent structural motifs in pharmaceuticals. Examples include axitinib (a tyrosine kinase inhibitor), albendazole (a treatment for parasitic worm infestations), vortioxetine (an antidepressant), and fenticonazole (an antifungal) [2]. In this project, the optimum conditions for reaction such as solvent type, temperature type are studied, in order to finally obtain a product with purity and acceptable yield. Various benefits, such as relatively short response times, simple purifications, good to excellent yields are among the important features of the proposed method.