Efflux Pump Inhibitors Derived From Natural Sources as Novel Antibacterial Agents Against Pseudomonas aeruginosa: A Review
Publish place: International Journal of Medical Reviews، Vol: 5، Issue: 3
Publish Year: 1397
نوع سند: مقاله ژورنالی
زبان: English
View: 458
This Paper With 12 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_IJMR-5-3_003
تاریخ نمایه سازی: 29 خرداد 1398
Abstract:
Infections resulting from Pseudomonas aeruginosa are important due to their highest resistance against all clinically used antibiotics. To date, 11 different efflux pumps of the RND family in P. aeruginosa that enable the efflux of antibiotics/anti-microbial production have been detected. Carvacrol of Satureja khuzestanica is one of the most effective compounds with the ability to affect bacteria. This study aimed to evaluate herbal compounds with inhibitory activities. These pumps include MexAB-OprM, MexCD-OprJ, MexEF-OprN, MexGHI-OpmD, MexJK-OprM/OpmH, MexMN, MexPQ-OpmE, MexVW-OprM, MexXY-OprM, TriABC-OpmH, and MuxABC-OpmB (1). Unfortunately, among bacteria, P. aeruginosa are highly resistant to drug compounds (3). Because of this high resistance, its importance in nosocomial infections and burns, and that it often causes diseases in immunocompromised patients, finding a therapeutic supplement is essential. In this study, drug compounds against efflux pump genes were sought.
Keywords:
Authors
Davood Iman Islamieh
Department of Microbiology and Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
Davoud Afshar
Department of Microbiology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
Masoud Yousefi
Department of Microbiology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
Davoud Esmaeili
Department of Microbiology and Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
مراجع و منابع این Paper:
لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :