Evaluation of the effects of the hydroalcoholic extract of Terminalia chebula fruits on diazinon-induced liver toxicity and oxidative stress in rats

Publish Year: 1396
نوع سند: مقاله ژورنالی
زبان: English
View: 284

This Paper With 13 Page And PDF Format Ready To Download

  • Certificate
  • من نویسنده این مقاله هستم

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این Paper:

شناسه ملی سند علمی:

JR_AJP-7-5_008

تاریخ نمایه سازی: 18 تیر 1398

Abstract:

Objective: Diazinon causes oxidative stress and dysfunction of the liver. This study was undertaken to evaluate the effects of the hydroalcoholic extract of Terminalia chebula, on some biochemical and histopathological parameters of liver tissue in diazinon-administered rats. Materials and Methods: Wistar rats were orally administered with 25 mg/kg body weight diazinon. Vehicle (distilled water) and silymarin (50 mg/kg body weight) were used as the negative and positive control groups, respectively. Diazinon-administered groups were treated with T.chebula (Terminalia chebula) fruit extract (200, 400, and 800 mg/kg). After 15 days of treatment, the blood specimens and liver samples were examined. Results: In diazinon-treated group, the levels of serum urea, high density lipoprotein (HDL), and liver superoxide dismutase (SOD), catalase (CAT), and vitamin C significantly decreased (p<0.05) compared to control. Also, in this group, serum triglyceride (TG), total cholesterol (TC), very low density lipoprotein cholesterol (VLDL), protein carbonyl (PC), malondialdehyde, tumor necrosis factor-α (TNF-α), and TNF-α gene expression significantly increased (p<0.05) as compared to the control (vehicle-treated rats). Treatment with T. chebula resulted in a significant increase (p<0.05) in CAT, SOD, vitamin C, HDL and a significant  decrease (p<0.05) in the level of urea, MDA, PC, TG, TC, VLDL, TNF-α protein, and the gene expression of TNF-α compared with test without treatment group. Histopathological evidence demonstrated that treatment with T. chebula extract could decrease liver lymphocyte infiltration. Conclusion: The present study suggests that T. chebula fruit extract has protective effects against diazinon-induced oxidative stress.

Authors

Raheleh Ahmadi-Naji

Student Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran

Esfandiar Heidarian

Clinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran

Keyhan Ghatreh-Samani

Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran

مراجع و منابع این Paper:

لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :
  • Abdel-Daim MM. 2016. Synergistic protective role of ceftriaxone and ascorbic ...
  • Ahmed MA, Ahmed HI, El-Morsy EM. 2013. Melatonin protects against ...
  • Al-Attar AM. 2015. Effect of grapeseed oil on diazinon-induced physiological ...
  • Al-Attar AM, Abu Zeid IM. 2013. Effect of tea (Camellia ...
  • Ansari MA, Raish M, Ahmad A, Ahmad SF, Mudassar S, ...
  • Bag A, Kumar Bhattacharyya S, Kumar Pal N, Ranjan Chattopadhyay ...
  • Balkan J, KANBAGli Ö, Aykaç-Toker G, Uysal M. 2002. Taurine ...
  • Beauchamp C, Fridovich I. 1971. Superoxide dismutase: Improved assays and ...
  • Bhattacharya S, Chaudhuri SR, Chattopadhyay S, Bandyopadhyay SK. 2007. Healing ...
  • Bradford MM. 1976. A rapid and sensitive method for the ...
  • Carleton HM, Drury RAB, Wallington EA (1980) Carleton s histological ...
  • Chandra GP. 2012. Biological and pharmacological properties of Terminalia ChebulaRetz.(Haritaki)-An ...
  • Chang C-C, Yang M-H, Wen H-M, Chern J-C. 2002. Estimation ...
  • Donnahoo KK, Meng X, Ayala A, Cain MP, Harken AH, ...
  • El-Shenawy NS, El-Salmy F, Al-Eisa RA, El-Ahmary B. 2010. Amelioratory ...
  • Farahpour MR, Mirzakhani N, Doostmohammadi J, Ebrahimzadeh M. 2015. Hydroethanolic ...
  • Friedewald WT, Levy RI, Fredrickson DS. 1972. Estimation of the ...
  • Gokcimen A, Gulle K, Demirin H, Bayram D, Kocak A, ...
  • Hariri AT, Moallem SA, Mahmoudi M, Memar B, Hosseinzadeh H. ...
  • Hassouna I, Ibrahim H, Abdel Gaffar F, El-Elaimy I, Abdel ...
  • Heidarian E, Jafari-Dehkordi E, Seidkhani-Nahal A. 2011. Lipid-lowering effect of ...
  • Heidarian E, Keloushadi M, Ghatreh-Samani K, Valipour P. 2016. The ...
  • Heidarian E, Rafieian-Kopaei M. 2012. Effect of silymarin on liver ...
  • Heidarian E, Rafieian-Kopaei M. 2013. Protective effect of artichoke (Cynara ...
  • Heidarian E, Rafieian-Kopaei M, Khoshdel A, Bakhshesh M. 2014. Metabolic ...
  • Heidarian E, Saffari J, Jafari-Dehkordi E. 2014. Hepatoprotective action of ...
  • Heidarian E, Soofiniya Y. 2011. Hypolipidemic and hypoglycemic effects of ...
  • Kannan VR, Rajasekar GS, Rajesh P, Balasubramanian V, Ramesh N, ...
  • Karimi-Khouzani O, Heidarian E, Amini SA. 2017. Anti-inflammatory and ameliorative ...
  • Korou L-M, Bakoyiannis I, Metaxas P, Doulamis I, Konstadopoulos P, ...
  • Kose E, Sapmaz HI, Sarihan E, Vardi N, Turkoz Y, ...
  • Lari P, Abnous K, Imenshahidi M, Rashedinia M, Razavi M, ...
  • Lee H-S, Won NH, Kim KH, Lee H, Jun W, ...
  • Lichter-Konecki U. 2016. Defects of the urea cycle. Transl Sci ...
  • Lukaszewicz-Hussain A. 2010. Role of oxidative stress in organophosphate insecticide ...
  • McDonald S, Prenzler PD, Antolovich M, Robards K. 2001. Phenolic ...
  • Messarah M, Amamra W, Boumendjel A, Barkat L, Bouasla I, ...
  • Nouri A, Heidarian E, Nikoukar M. 2017. Effects of N-acetyl ...
  • Omar HA, Mohamed WR, Arab HH, Arafa E-SA. 2016. Tangeretin ...
  • Omaye S, Turnbull J, Sauberlich H. 1979. Selected methods for ...
  • Posadzki P, Watson LK, Ernst E. 2013. Adverse effects of ...
  • Rezaei A, Heidarian E. 2013. Co-administration of trientine and flaxseed ...
  • Reznick AZ, Packer L. 1994. Oxidative damage to proteins: Spectrophotometric ...
  • Sahu BD, Tatireddy S, Koneru M, Borkar RM, Kumar JM, ...
  • Singh R, Singh N, Saini B, Rao HS. 2008. In ...
  • Sireeratawong S, Jaijoy K, Panunto W, Nanna U, Lertprasertsuke N, ...
  • Valipour P, Heidarian E, Khoshdel A, Gholami-Arjenaki M. 2016. Protective ...
  • Wullaert A, Heyninck K, Beyaert R. 2006. Mechanisms of crosstalk ...
  • نمایش کامل مراجع