Aplication of Smart Biomaterials for Cell Encapsulation
Publish place: International Conference on Recent Developments in Information Science, Engineering and Technology
Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
ICIETCONF01_007
تاریخ نمایه سازی: 1 مرداد 1398
Abstract:
For long-term cell encapsulation, besides overcoming suffocation, how to promote blood vessel formation in and/or surrounding the implanted. Biomaterials are extremely challenging. As a new trend towards smart biomaterials, researchers are trying to design new encapsulating materials to control cell behavior by closely mimicking the natural in vivo cellular microenvironment, such as by providing the necessary signaling molecules, and biophysical and bioactive cues. In order to control neovasculature development, it s important to figure out which regulator factors and cell types affect the formation of blood vessels. Well studied angiogenesis stimulatory factors include fibroblast growth factor (bFGF), certain matrix metalloproteinases (MMPs), vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF). There are numerous cell types involved in vascular networks, such as vascular endothelial cells (VECs), smooth muscle cells (VSMCs) and mesenchymal stem cells (MSCs). Based on this knowledge of vascularization, vascularized biomaterials have been developed through various strategies. Stem cells are non-specialized cells that could either proliferate to expand the stem cell population or differentiate into various other cell types during their development. In this study, these factors have been investigated.
Keywords:
Authors
Mehdi Movahedi
Biomedical Engineering Department, Islamic Azad University Science and Research Branch
Reyhaneh yarahmadian
Department of materials Engineering, Isfahan University of Technology