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Co(NO3)2: An Efficiental Catalyst for Synthsis of Dihydropyrimido[4,5- b]quinolinetrione Derivatives Using a Multi-Component Reaction

Publish Year: 1397
Type: Conference paper
Language: English
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ISOC26_123

Index date: 24 August 2019

Co(NO3)2: An Efficiental Catalyst for Synthsis of Dihydropyrimido[4,5- b]quinolinetrione Derivatives Using a Multi-Component Reaction abstract

Pyrimidine derivatives have a biological and medicinal activity such as anticancer and antihumanimmunodeficiency virus (HIV). Pyrimidine fused heterocycles have attracted great interestand biological activities such as inflammatory, antioxidant, anticancer, antitumour, antimicrobial,and antiviral actions from pyrimidine fused heterocycles have been reported.Many of alkaloids, drugs, antibiotics, agrochemicals, and natural products contain pyrimidinefused heterocycles [1]. Multicomponent reactions (MCRs) are an attractive strategy, in thefield of medicinal chemistry and used to obtain desired biologically active compounds [2]. Inthis study Co(NO3)2 has been introduced as efficient catalyst for synthesis of the novel8,9-dihydro-8,8-dimethyl-5,10-diphenylpyrimido[4,5-b]quinoline-2,4,6(1H,3H,5H,7H,10H)-trionederivatives via a four-component reaction of aldehydes, amines, dimedone, and barbituricacid with high efficiency and sutable time.

Co(NO3)2: An Efficiental Catalyst for Synthsis of Dihydropyrimido[4,5- b]quinolinetrione Derivatives Using a Multi-Component Reaction authors

Zeinab Hataminegzad

Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran

Nourallah Hazeri

Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran

Sara Hosseinzadegan

Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran

Mohammadreza Moghadam-Manesh

Department of Chemistry, Faculty of Science, Kerman Branch, Islamic Azad University, Kerman, Iran- General Bureau of Standard Sistan and Baluchestan Province, Iranian National Standards