One-pot synthesis of 2-oxo-1,2,3,4-tetrahydropyrimidines using homogeneous catalyst under solvent-free conditions
Publish place: Iranian Chemical Communication، Vol: 5، Issue: 1
Publish Year: 1395
نوع سند: مقاله ژورنالی
زبان: English
View: 404
This Paper With 7 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_ICC-5-1_005
تاریخ نمایه سازی: 2 مهر 1398
Abstract:
The chemistry of 2-oxo-1,2,3,4-tetrahydropyrimidines began to develop toward the end of 1893 year, when the first representatives of this class compounds were reported by P. Biginelli. Despite prior reports of several really effective catalytic and non-catalytic approaches towards Biginelli-type products, an overwhelming number of new catalysts for the Biginelli reaction have been recently published. Most of the catalysts are somewhat exotic, expensive, harmful and even ineffective in the absence of acidic additives. This work reports on the preparation of 2-oxo-1,2,3,4-tetrahydropyrimidines using the NaF as catalyst. One-pot condensation reactions were carried out for various aryl aldehydes, ethyl acetoacetate, acetyl acetone and urea under solvent-free conditions at 100 °C and afforded the target molecules in good to excellent yields. The advantages of this method are high yield of product, short reaction time, and separation of this catalyst is very comfortable. Furthermore, according to the experimental data, we have proposed the suitable mechanism.
Keywords:
Authors
Asadollah Farhadi
petroleum university of technology of ahwaz
Mohammad Ali Takassi
Petroleum University of Technology Ahwaz
Lila Hejazi
Petroleum University of Technology Ahwaz
مراجع و منابع این Paper:
لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :