Mycosis Fungoides Skin Wound Management With Skin Graft Post Ultraviolet Radiation therapy

Objective : To assess the survival rate of skin graft management in skin lesions of mycosis fungoides patientsafter therapy with ultraviolet radiation.Methods : Between February. 2011 and June 2015, 89 [8- 81 yrs. ] mycosis fungoides patients werefollowed up at dermatology clinic, the initial investigations were skin biopsy and the most common usedtherapy is photo therapy with ultraviolet radiation ( according to stage in the histopathologic reports )Results : Of the 89 patients that we followed , 90% treated with phototherapy (80 patients ), 35% of them (28patients ) of these patients were managed by skin grafts of skin lesions and ulcers , 10% of them ( 3patients )the skin graft didn’t survive without previous therapy with ultraviolet radiation , 90% (25patients ) of them thegrafted areas survived after phototherapy of UVA ,UVB radiation to the potential donor site, the other 65%(52patients ) of the followed pts were managed without skin graft for the ulcerated skin lesions , 38% of themhealed spontaneously , others didn’t healed for a long time and need skin graft.Conclusion: Mycosis fungoides is the most common type of cutaneous T lymphoma, pts who receivedphototherapy to the potential donor site has proven beneficial for skin graft survival , since ultraviolet radiationA,B ,decrease the cytotoxic T lymphocyte activity and decrease inflammatory cells in both graft and donortissues , with decrease in the antigen presenting cells expression, which leads to decrease in the delayed typehyper sensitivity reaction and increase graft uptake.

Keywords:

Mycosis fungoides , skin graft , phototherapy