A Systematic Overview Of The Role Helicobacter Pylori On Polycystic Ovary Syndrome

Background: Polycystic ovary syndrome (PCOs) is one of the most common endocrinopathies that affects about 6-8 % of women of reproductive age. Helicobacter pylori is the most common pathogenic bacteria in the world, that Approximately half of the population worldwide has H.pylori infection. Chronic systemic inflammation has been considered to play a role in the development of PCOs. Helicobacter pylori has been shown to lead to chronic systemic inflammation. Therefore, the present study was to investigate with the aim of systematically reviewing the studies on possible link between H.pylori and PCOs.Material and Method: In this systematic review was performed using the key words Helicobacter pylori AND PCOs in Scopus, PubMed, ScienceDirect, Google Scholar, Iranmedex databases, Until March 2019, and finally 21 articles were examined in this regard.Result: Helicobacter pylori is recognised as the most important etiological agent for chronic antral gastritis in humans, and probable cofactor in the development of gastric cancer, MALT-lymphoma, variety of extradigestive disorders including cardiovascular, skin, rheumatic, and respiratory diseases. The activation of inflammatory mediators by H.pylori seems to be the common pathogenetic mechanism underlying the observed associations. Helicobacter pylori may be implanted in the female reproductive system due to the similarity of gastric and vaginal cells and may be transmitted sexually, using the human female vagina as a reservoir for transmission. In some studies, increased levels of PCOs and decreased total antioxidant status were found H.pylori-infected patients. Therefore, there is a possible association between H.pylori seropositivity and PCOs.Conclusion: Based on the fact that in women with PCOs, the hypothesis of the role of Helicobacter pylori can be suggested as a risk factor for this disease, treatment H.pylori infections is required for decreasing the oxidative stress, which synergistically brings about an appropriate correction of PCOs soon in these patients

Keywords:

Polycystic ovary syndrome , Helicobacter pylori , Antioxidant.