Publisher of Iranian Journals and Conference Proceedings

Please waite ..
CIVILICAWe Respect the Science
Publisher of Iranian Journals and Conference Proceedings
عنوان
Paper

Androgen Excess During Fetal Life Affects Rats Cardiac Function in Adulthood

تعداد صفحات: 1 | تعداد نمایش خلاصه: 80 | نظرات: 0
سال انتشار: 1398
کد COI Paper: COBGY15_223
زبان Paper: Englishglish
متن کامل این Paper منتشر نشده است و فقط به صورت چکیده یا چکیده مبسوط در پایگاه موجود می باشد.
توضیح: معمولا کلیه مقالاتی که کمتر از ۵ صفحه باشند در پایگاه سیویلیکا اصل Paper (فول تکست) محسوب نمی شوند و فقط کاربران عضو بدون کسر اعتبار می توانند فایل آنها را دریافت نمایند.

مشخصات نویسندگان Paper Androgen Excess During Fetal Life Affects Rats Cardiac Function in Adulthood

Mahsa Noroozzadeh - Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Mohammad Reza Raoufi - Faculty of Medical Sciences, Tarbiat Modares University, Iran Tehran University of Medical Sciences Department of Epidemiology and Biostatistics-Iran, Tehran
Farzaneh Faraji Shahrivar - Faculty of Medicine, Iranshahr University of Medical Sciences, Iran, Iran
Fahimeh Ramezani Tehrani - Endocrinology Research Institute Shahid Beheshti University of Medical Sciences Endocrine Research Center - Iran, Tehran

چکیده Paper:

Backgrounds: Developmental programming is a complex process whereby the hormonal, nutritional, and metabolic disturbances occurring during the critical period of intrauterine development lead to alterations in the developmental trajectory of the growing fetus. The origin of cardiovascular diseases may arise from suboptimal intrauterine environments such as disturbed hormonal milieu. We aimed to compare the effects of prenatal androgen exposure(PAE) on heart basal hemodynamic parameters and tolerance to ischemia/reperfusion(I/R) injury among PAE adult female and male rats.Material and Method: Pregnant Wistar rats in the experimental group(n=8) received 5 mg of testosterone by s.c. injection on the 20th day of pregnancy and controls(n=8) received solvent. Female and male offspring experimental (n=16) and control (n=16) rats were kept with ad libitum food and water. In adulthood, the hearts of rats were isolated and perfused in a Langendorff apparatus, values of the hemodynamic parameters including: left ventricular end-diastolic pressure(LVEDP), left ventricular systolic pressure(LVSP), left ventricular developed pressure (LVDP), heart rate(HR), rate pressure product(RPP) and peak rates of positive and negative changes in left ventricular pressure(±dp/dt) were continuously recorded before(baseline) and after myocardial I/R, using a power lab system.Result: At baseline: PAE adult males demonstrated significant higher amount of LVSP, LVDP, RPP and ±dp/dt, compared to their controls and PAE adult females(p<0.05), while PAE adult females showed no significant differences compared to their controls. After I/R: In PAE adult males, LVSP, LVDP, RPP and ±dp/dt had significant decreasing trends per phases after I/R, compared to their controls and PAE females, while these decreasing trends were not statistically significant in PAE adult female rats vs. their controls. Conclusion:The impact of prenatal androgen exposure on adulthood cardiac function and tolerance to I/R is gender dependent, which may be partly explained by different cardiac effects of hyperandrogenism in males versus females. After prenatal androgen exposure, the baseline hemodynamic parameters of the hearts of adult males are increased; although they had less tolerance to I/R, findings however not observed in females.

کد Paper/لینک ثابت به این Paper

برای لینک دهی به این Paper می توانید از لینک زیر استفاده نمایید. این لینک همیشه ثابت است و به عنوان سند ثبت Paper در مرجع سیویلیکا مورد استفاده قرار میگیرد:

https://civilica.com/doc/954226/

کد COI Paper: COBGY15_223

نحوه استناد به Paper:

در صورتی که می خواهید در اثر پژوهشی خود به این Paper ارجاع دهید، به سادگی می توانید از عبارت زیر در بخش منابع و مراجع استفاده نمایید:
undefined, undefined و undefined, undefined و undefined, undefined و undefined, undefined,1398,Androgen Excess During Fetal Life Affects Rats Cardiac Function in Adulthood,پانزدهمین کنگره بین المللی زنان و مامایی ایران,Tehran,,,https://civilica.com/doc/954226

در داخل متن نیز هر جا که به عبارت و یا دستاوردی از این Paper اشاره شود پس از ذکر مطلب، در داخل پارانتز، مشخصات زیر نوشته می شود.
برای بار اول: (1398, Noroozzadeh, Mahsa؛ Mohammad Reza Raoufi و Farzaneh Faraji Shahrivar و Fahimeh Ramezani Tehrani)
برای بار دوم به بعد: (1398, Noroozzadeh؛ Raoufi و Faraji Shahrivar و Ramezani Tehrani)
برای آشنایی کامل با نحوه مرجع نویسی لطفا بخش راهنمای سیویلیکا (مرجع دهی) را ملاحظه نمایید.

Research Info Management

Certificate | Report Paper

Export Citation info of this Paper to research management softwares

علم سنجی و رتبه بندی Paper

مشخصات مرکز تولید کننده این Paper به صورت زیر است:
نوع مرکز: medical university
تعداد مقالات: 3,573
در بخش علم سنجی پایگاه سیویلیکا می توانید رتبه بندی علمی مراکز دانشگاهی و پژوهشی کشور را بر اساس آمار مقالات نمایه شده مشاهده نمایید.

New RelatedPapers

Share this paper

WHAT IS COI?

COI is a national code dedicated to all Iranian Conference and Journal Papers. the COI of each paper can be verified online.

Support