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Title

Promoter Methylation of Four Tumor Suppressor Genes in Human Papillary Thyroid Carcinoma

Year: 1398
COI: JR_IJP-14-4_004
Language: EnglishView: 231
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Authors

Fatemeh Khatami - Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
Bagher Larijani - Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
Ramin Heshmat - Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
Shirzad Nasiri - Department of Surgery, Tehran University of Medical Sciences, Shariati Hospital, Tehran, Iran

Abstract:

Background & Objective: Papillary thyroid cancer (PTC) is considered to be the most common type of thyroid malignancies. Epigenetic alteration, in which the chromatin conformation and gene expression change without changing the sequence of DNA, can occur in some tumor suppressor genes and oncogenes. Methylation is the most common type of epigenetic alterations that can be an excellent indicator of PTC invasive behavior. Methods: In this research, we determined the promoter methylation status of four tumor suppressor genes (SLC5A8, RASSF1, MGMT, and DNMT1) and compared the results of 55 PTC cases with 40 goiter patients. For methylation, we used the methylation-sensitive high resolution melting (MS-HRM) assay technique. The resulting graphs of each run were compared with those of 0%, 50%, and 100% methylated controls. Results: Our data showed that the promoter methylation of SLC5A8, Ras association domain family member 1(RASSF1), and MGMT were significantly different between PTC tissue and goiter with P-value less than 0.05. The most significant differences were observed in RASSF1; 77.2% of hyper-methylated PTC patients versus 15.6% hyper-methylated goiter samples (P<0.001). Conclusion: RASSF1 promoter methylation can be a PTC genetic marker. RASSF1 promoter methylation is under the impact of the methyltransferase genes (DNMT1 and MGMT), protein expression, and promoter methylation.

Keywords:

Tumor suppressor genes, Methylation, Papillary thyroid cancers

Paper COI Code

This Paper COI Code is JR_IJP-14-4_004. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/963985/

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Khatami, Fatemeh and Larijani, Bagher and Heshmat, Ramin and Nasiri, Shirzad,1398,Promoter Methylation of Four Tumor Suppressor Genes in Human Papillary Thyroid Carcinoma,https://civilica.com/doc/963985

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  • Goodall C. On para‐endocrine cancer syndromes. International Journal of Cancer. ...
  • Sipos J, Mazzaferri E. Thyroid cancer epidemiology and prognostic variables. ...
  • Khatami F, Tavangar SM. Genetic and Epigenetic of Medullary Thyroid ...
  • Pellegriti G, Frasca F, Regalbuto C, Squatrito S, Vigneri R. ...
  • Aschebrook-Kilfoy B, Ward MH, Sabra MM, Devesa SS. Thyroid cancer ...
  • Larijani B, Shirzad M, Mohagheghi M, Haghpanah V, Mosavi-Jarrahi A, ...
  • Haghpanah V, Soliemanpour B, Heshmat R, Mosavi-Jarrahi A, Tavangar S, ...
  • Larijani B, Mohagheghi MA, Bastanhagh MH, Mosavi-Jarrahi AR, Haghpanah V, ...
  • Sosa JA, Udelsman R. Papillary thyroid cancer. Surgical Oncology Clinics. ...
  • Spartalis ED, Karatzas T, Charalampoudis P, Vergadis C, Dimitroulis D. ...
  • Erden ES, Babayigit C, Davran R, Akin M, Karazincir S, ...
  • Borschitz T, Eichhorn W, Fottner C, Hansen T, Schad A, ...
  • Sherman SI, Tielens ET, Sostre S, Wharam Jr M, Ladenson ...
  • Haddadi-Nezhad S, Larijani B, Tavangar SM, Nouraei SM. Comparison of ...
  • Greenblatt DY, Woltman T, Harter J, Starling J, Mack E, ...
  • Grogan RH, Mitmaker EJ, Clark OH. The evolution of biomarkers ...
  • Sanii S, Saffar H, Tabriz HM, Qorbani M, Haghpanah V, ...
  • Saffar H, Sanii S, Emami B, Heshmat R, Panah VH, ...
  • Haghpanah V, Lashkari A, Moradzadeh K, Tavangar SM. Hypereosinophilia as ...
  • Xing M. BRAF mutation in thyroid cancer. Endocrine-related cancer. 2005;12(2):245-62. ...
  • Faam B, Ghaffari MA, Ghadiri ATA, Azizi F. Epigenetic modifications ...
  • Mohammadi-Asl J, Larijani B, Khorgami Z, Tavangar S, Haghpanah V, ...
  • Omidfar K, Moinfar Z, Sohi AN, Tavangar SM, Haghpanah V, ...
  • Haghpanah V, Shooshtarizadeh P, Heshmat R, Larijani B, Tavangar SM. ...
  • El Demellawy D, Nasr A, Alowami S. Application of CD56, ...
  • Tavangar S, Monajemzadeh M, Larijani B, Haghpanah V. Immunohistochemical study ...
  • Amoli MM, Yazdani N, Amiri P, Sayahzadeh F, Haghpanah V, ...
  • Sabetkish S, Kajbafzadeh AM, Sabetkish N, Khorramirouz R, Akbarzadeh A, ...
  • Kajbafzadeh A-M, Payabvash S, Salmasi AH, Monajemzadeh M, Tavangar SM. ...
  • NASSERI‐MOGHADDAM S, Malekzadeh R, Sotoudeh M, Tavangar M, Azimi K, ...
  • Natanzi MM, Pasalar P, Kamalinejad M, Dehpour AR, Tavangar SM, ...
  • Tavangar SM, Shojaee A, Tabriz HM, Haghpanah V, Larijani B, ...
  • Sarmadi S, Izadi-Mood N, Sotoudeh K, Tavangar SM. Altered PTEN ...
  • Alimoghaddam K, Shariftabrizi A, Tavangar M, Sanaat Z, Rostami S, ...
  • Tavangar SM, Larijani B, Mahta A, Hosseini SMA, Mehrazine M, ...
  • Khatami F, Mohammadamoli M, Tavangar SM. Genetic and epigenetic differences ...
  • Hayes DF, Bast RC, Desch CE, Fritsche Jr H, Kemeny ...
  • Herceg Z, Hainaut P. Genetic and epigenetic alterations as biomarkers ...
  • Khatami F, Payab M, Sarvari M, Gilany K, Larijani B, ...
  • Kulasingam V, Diamandis EP. Strategies for discovering novel cancer biomarkers ...
  • Xing M. Gene methylation in thyroid tumorigenesis. Endocrinology. 2007;148(3):948-53. [DOI:10.1210/en.2006-0927] ...
  • Phillips T. The role of methylation in gene expression. Nature ...
  • Suzuki MM, Bird A. DNA methylation landscapes: provocative insights from ...
  • Smith JA, Fan C-Y, Zou C, Bodenner D, Kokoska MS. ...
  • Hu S, Liu D, Tufano RP, Carson KA, Rosenbaum E, ...
  • Xing M, Cohen Y, Mambo E, Tallini G, Udelsman R, ...
  • Mohammadi-asl J, Larijani B, Khorgami Z, Tavangar SM, Haghpanah V, ...
  • Lim AM, Candiloro IL, Wong N, Collins M, Do H, ...
  • Mikeska T, Candiloro IL, Dobrovic A. The implications of heterogeneous ...
  • Wittwer CT, Reed GH, Gundry CN, Vandersteen JG, Pryor RJ. ...
  • Wojdacz TK, Dobrovic A. Methylation-sensitive high resolution melting (MS-HRM): a ...
  • Wojdacz TK, Dobrovic A, Hansen LL. Methylation-sensitive high-resolution melting. Nature ...
  • Hussmann D, Hansen LL. Methylation-Sensitive High Resolution Melting (MS-HRM). DNA ...
  • Dahl C, Grønskov K, Larsen LA, Guldberg P, Brøndum-Nielsen K. ...
  • Brigliadori G, Foca F, Dall Agata M, Rengucci C, Melegari ...
  • Quillien V, Lavenu A, Karayan‐Tapon L, Carpentier C, Labussière M, ...
  • Xie H, Tubbs R, Yang B. Detection of MGMT promoter ...
  • Esteller M, Corn PG, Baylin SB, Herman JG. A gene ...
  • Baylin SB. DNA methylation and gene silencing in cancer. Nature ...
  • Moore LD, Le T, Fan G. DNA Methylation and Its ...
  • Lopatina N, Haskell JF, Andrews LG, Poole JC, Saldanha S, ...
  • Yokochi T, Robertson KD. Preferential methylation of unmethylated DNA by ...
  • Robert M-F, Morin S, Beaulieu N, Gauthier F, Chute IC, ...
  • Nuñez NN, Manlove AH, David SS. DNMT1 and Cancer: An ...
  • Rahmani T, Azad M, Chahardouli B, Nasiri H, Vatanmakanian M, ...
  • Novakovic B, Wong NC, Sibson M, Ng H-K, Morley R, ...
  • Bennett KL, Karpenko M, Lin MT, Claus R, Arab K, ...
  • Sharma S, Kelly TK, Jones PA. Epigenetics in cancer. Carcinogenesis. ...
  • Gömöri É, Pál J, Kovács B, Dóczi T. Concurrent hypermethylation ...
  • Li D, Bi F-F, Cao J-M, Cao C, Liu B, ...
  • Khatami F, Mohebi SR, Ghiasi S, Haghighi MM, Safaee A, ...
  • Cai Y, Tsai H-C, Yen R-WC, Zhang YW, Kong X, ...
  • Zhang Y, Sun B, Huang Z, Zhao D-W, Zeng Q. ...
  • Brehar A, Procopiuc C, Paun D, Manda D, Oros S, ...
  • Cai Y, Tsai H-C, Yen R-WC, Zhang YW, Kong X, ...
  • Tano K, Shiota S, Collier J, Foote RS, Mitra S. ...
  • Natarajan A, Vermeulen S, Darroudi F, Valentine MB, Brent TP, ...
  • Halford S, Rowan A, Sawyer E, Talbot I, Tomlinson I. ...
  • CAbRINI G, FAbbRI E, Lo Nigro C, DEChECChI MC, GAMbARI ...
  • Nakagawachi T, Soejima H, Urano T, Zhao W, Higashimoto K, ...
  • Zhang W, Zhang J, Hoadley K, Kushwaha D, Ramakrishnan V, ...
  • Soejima H, Zhao W, Mukai T. Epigenetic silencing of the ...
  • Osanai T, Takagi Y, Toriya Y, Nakagawa T, Aruga T, ...
  • Costello JF, Futscher BW, Tano K, Graunke DM, Pieper RO. ...
  • Esteller M, Hamilton SR, Burger PC, Baylin SB, Herman JG. ...
  • Esteller M, Risques R-A, Toyota M, Capella G, Moreno V, ...
  • Herfarth KKF, Brent TP, Danam RP, Remack JS, Kodner IJ, ...
  • Stephen J, Chen K, Merritt J, Chitale D, Divine G, ...
  • Santos JC, Bastos AU, Cerutti JM, Ribeiro ML. Correlation of ...
  • Gopal E, Fei Y-J, Sugawara M, Miyauchi S, Zhuang L, ...
  • Takebe K, Nio J, Morimatsu M, Karaki S-I, Kuwahara A, ...
  • Iwanaga T, Takebe K, Kato I, Karaki S-I, Kuwahara A. ...
  • Martin PM, Gopal E, Ananth S, Zhuang L, Itagaki S, ...
  • Galrão AL, Camargo RY, Friguglietti CU, Moraes L, Cerutti JM, ...
  • Khatami F, Larijani B, Heshmat R, Keshtkar A, Mohammadamoli M, ...
  • Schagdarsurengin U, Gimm O, Dralle H, Hoang-Vu C, Dammann R. ...
  • Porra V, Ferraro-Peyret C, Durand C, Selmi-Ruby S, Giroud H, ...
  • Schagdarsurengin U, Gimm O, Dralle H, Hoang-Vu C, Dammann R. ...
  • Pabalan N, Kunjantarachot A, Ruangpratheep C, Jarjanazi H, Christofolini DM, ...
  • Tommasi S, Dammann R, Zhang Z, Wang Y, Liu L, ...
  • Amato E, Barbi S, Fassan M, Luchini C, Vicentini C, ...
  • Vos MD, Ellis CA, Bell A, Birrer MJ, Clark GJ. ...
  • Xu H, Zhan W, Chen Z. Ras-Association Domain Family 1 ...
  • Grawenda A, O neill E. Clinical utility of RASSF1A methylation ...
  • da Costa Prando É, Cavalli LR, Rainho C. Evidence of ...
  • Shao C, Dai W, Li H, Tang W, Jia S, ...
  • Huang Y, Guan H, Liu C, Liu D, Xu B, ...
  • Wen G, Wang H, Zhong Z. Associations of RASSF1A, RARβ, ...
  • Schagdarsurengin U, Gimm O, Hoang-Vu C, Dralle H, Pfeifer GP, ...
  • Nakamura N, Carney JA, Jin L, Kajita S, Pallares J, ...
  • Zhang K, Li C, Liu J, Tang X, Li Z. ...
  • Niu H, Yang J, Yang K, Huang Y. The relationship ...
  • Bai J, Zhang X, Hu K, Liu B, Wang H, ...
  • Zhang H, He J, Li J, Tian D, Gu L, ...
  • Puto LA, Reed JC. Daxx represses RelB target promoters via ...
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