Evaluating the role of cinnamon hydroalcoholic extract on morphine deprivation syndrome and subsequent depression in male mice

Background and Aim : These days addiction is one of the fundamental problems of human societies. Duo to the side effects of chemical drugs on addiction, finding plants with similar properties can be helpful. Cinnamon is a medicinal plant posing various effects. Cinnamon contains chemicals components such as cinnamaldehyde. Previous research has suggested the antidepressant effects of cinnamon. Goal: In this study, we decide to investigate the anti-addictive effects of cinnamon and examine its effects on depression.Methods : In this study, 21 male mice were divided into 3 groups: control, morphine and morphine + cinnamon. The morphine was administrated four-day period in order to induce addiction. The group also received intraperitoneal injection of cinnamon extract at doses 500 mg / kg of morphine each time. At the end of the procedure after injecting naloxone, morphine deprivation syndrome behaviors were assessed, and finally depression behaviors were examined.Results : according to our result cinnamon extract improved morphine withdrawal behaviors in the extract receiving group. In addition, in this group depression was lower than the morphine group.Conclusion : Cinnamon extract reduced morphine effects and subsequent morphine withdrawal behaviors due to its chemical components affecting the dopaminergic system. On the other hand, due to the sedative compounds in cinnamon extract, it has been able to reduce the effects of depression.

Keywords:

Morphine , Cinnamon , Depression , Addiction