Evaluation of the preventive effects of Gallic acid on behavioral disorders and oxidative stress of brain following global cerebral ischemia/reperfusion in rats

Background and Aim : Global cerebral ischemia/reperfusion (I/R) may occur after any of several clinical conditions such as cardiac arrest and coma due to accident. In the present study we aimed to investigate the probable effects of gallic acid (GA) on spatial memory, depressive-like behavior, and oxidative stress induced by permanent arteria vertebralis heat-blocked and temporary carotid arteries occlusion/reperfusion (4VO) in rats.Methods : Fifty six male Wistar rats (250-300 g) were divided randomly into four groups; 1) Sham, 2) I/R, 3) GA + I/R and 4) Sham + GA. 4VO was induced after 10 days of pretreatment by GA. 72 h later 4VO induction behavioral tests, and oxidative stress evaluation were done.Results : The data showed that GA administration improved the spatial memory and depressive-like behavior in rats that were damaged by 4VO-I/R. In addition biochemical observations showed that the oxidative stress in the brain tissue were significantly improved in injured rats by 4VO-I/R who got GA (p <0.01).Conclusion : Our findings suggest that GA pretreatment can reverse behavioral disorders and reduce oxidative stress. These actions may induce by its antioxidant and anti-inflammatory properties.

Keywords:

cerebral ischemia , gallic acid , oxidative stress , behavioral disorders , rat