سیویلیکا را در شبکه های اجتماعی دنبال نمایید.

Intraperitoneal injection of Neuroaid on alteration of Stathmin levels in the prefrontal and striatum regions following total sleep deprivation in male Wistar rats

Publish Year: 1398
Type: Conference paper
Language: English
View: 406
این Paper فقط به صورت چکیده توسط دبیرخانه ارسال شده است و فایل کامل قابل دریافت نیست. برای یافتن Papers دارای فایل کامل، از بخش [جستجوی مقالات فارسی] اقدام فرمایید.

نسخه کامل این Paper ارائه نشده است و در دسترس نمی باشد

Export:

Link to this Paper:

Document National Code:

NSCMED08_574

Index date: 5 January 2020

Intraperitoneal injection of Neuroaid on alteration of Stathmin levels in the prefrontal and striatum regions following total sleep deprivation in male Wistar rats abstract

Background and Aim : Studies show that sleep is a fundamental need and is essential for survival. Long-term sleep deprivation has negative effects on health, memory, learning and mechanisms of neural plasticity.Stathmin is one of the important proteins involved in neural plasticity. Stathmin plays a key role in synaptic plasticity and consequently in neural plasticity by controlling microtubule stability and dendritic translocation of AMPA receptors. On the other hand, recent research shows that Neuroaid has neuroprotective property and can increase neural plasticity.Methods : In this study we investigated the effect of intraperitoneal injection of Neuroaid on alteration of Stathmin levels in the prefrontal and striatum regions following total sleep deprivation in male Wistar rats.Results : The results showed that sleep deprivation significantly reduced the Stathmin levels in the prefrontal and striatum regions.Conclusion : Intraperitoneal injection of Neuroaid compensates the decrease in neuronal plasticity caused by sleep deprivation and significantly increases the Stathmin levels in the prefrontal and striatum regions.

Intraperitoneal injection of Neuroaid on alteration of Stathmin levels in the prefrontal and striatum regions following total sleep deprivation in male Wistar rats Keywords:

Intraperitoneal injection of Neuroaid on alteration of Stathmin levels in the prefrontal and striatum regions following total sleep deprivation in male Wistar rats authors

Sepideh Zarei

Department of Pharmacology, Pharmaceutical Sciences, Tehran Medical Sciences, Islamic Azad University

Mohammad Nasehi

Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences, Islamic Azad university

Solmaz Khalifeh

Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences, Islamic Azad university

Mohammad-reza Zarrindast

Department of Pharmacology School of Medicine, Tehran University of Medical Sciences, Tehran, Iran