Inheritance Modes of congenital heart defects among Iranian patients

Introduction: Congenital heart defects (CHD) are the most common cause of life-threatening in human CHDs have a heterogeneous etiology. Genetic factors have been known to be involved in these types of defects. In this study, we present the frequency of different patterns of inheritance among Iranian families with CHDs.Materials and methods: This study was conducted on 100 affected families referred to Rajaie hospital. Pedigree drawing was performed for each family. Other information such as age of onset, gender, … were also documented. The pattern was considered as autosomal recessive, autosomal dominant mitochondrial, sporadic, and familial.Results: 55.76% had consanguineous marriages. Familial heritance was major mode of inheritance which 29.13% of families showed this type of inheritance. .Discussion and conclusion: CHDs have a strong genetic liability in Iran. Further studies are required to determine genetic basis of CHD in Iran.

Keywords:

Congenital heart defects , hereditary pattern , CHD , Iranian population