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Synthesis of dibenzofuran derivatives by Catellani s strategy in one pot

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Year: 2019
COI code: ICCO02_016
Paper Language: English

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Authors Synthesis of dibenzofuran derivatives by Catellani s strategy in one pot

  Mehran Ghasemi - Faculty of Chemistry, Kharazmi University, No. 43. Mofateh Street, Enghelab Ave., 15719-14911 Tehran, Iran
  Azizollah Habibi - Faculty of Chemistry, Kharazmi University, No. 43. Mofateh Street, Enghelab Ave., 15719-14911 Tehran, Iran

Abstract:

Benzofuran derivatives are an important heterocyclic compounds that are possess vital biological activities such as antidepressant,anticancer, antiviral, antifungal, antioxidant, anti-psychotic etc. [1] Substituted benzofurans also posses other applications such asfluorescent sensor, antioxidants, oxidant, brightening agents and in other field of chemistry and agriculture. Benzofurans presents invarious natural products with various physiological, pharmacological and toxic properties. Due to the biological properties ofBenzofuran, there have been many reports of synthesis of this compounds in the last decade. [2] One of the attractive ways to synthesisof different compounds is to use Catellani s strategy. [3] In this approach it is possible to functionalization two positions in a one pot.In this work, this strategy was used to synthesis of dibenzofurans. 2-iodotoulene derivatives have been used as a source of iodoarene.The reaction includes the Ullmann type reaction and the arylation of ortho-position of aryl halide. Thus, the process involves Ullmanncoupling to ipso-position, and C-H activation at ortho-position. The reaction is carried out in the presence of the palladium acetate asa catalyst and the triphenylphosphine as a ligand, and cesium carbonate as a base. In this reaction, two bonds are formed in one pot,include a C-O bond and a C-C bond. The reason for the use of norbornene in this reaction is the activation of C-H bond, which iscommon in the catalytic reaction. Crucial to the mechanism of this reaction is the formation of palladacycle as an intermediate in thereaction in which C-H bond activation take place. So, this is a simple and economical way to synthesis of dibenzofuran.

Keywords:

dibenzofuran, C-H activation, palladium, catellani reaction

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COI code: ICCO02_016

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Ghasemi, Mehran & Azizollah Habibi, 2019, Synthesis of dibenzofuran derivatives by Catellani s strategy in one pot, 2nd Iranian Catalyst Conference, تهران- دانشگاه خوارزمي- دانشكده شيمي, دانشگاه خوارزمي, https://www.civilica.com/Paper-ICCO02-ICCO02_016.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Ghasemi, Mehran & Azizollah Habibi, 2019)
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Paper No.: 9369
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