Acetic Acid as a Green Catalyst for the Synthesis of N-Aminotriazolethione Azomethine Derivatives

Amino-mercapto-1,2,4-triazole are five-membered heterocycles compounds containing vicinalnucleophiles (NHR, SH) group which constitutes a ready-made building block for constructionof various organic heterocycles. 1,2,4-Triazoles ring attracts considerable attentionin organic chemistry owing to their biological activity [1] such as analgesic, antimicrobial,antiviral, antioxidant, anticancer, anticonvulsant, anti-inflammatory, and antihypertensiveproperties. Various methods have been reported for the synthesis of N-AminotriazolethioneAzomethine derivatives [2, 3]. In view of these above, we have reported the synthesis ofSchiff bases incorporating 1, 2, 4-triazole scaffold derived via green and efficient procedure.4-amino 5-methyl-1, 2, 4-triazole-3-thione with different aryl aldehydes resulted in the formationof the corresponding imines in the presence of acetic acid as the catalyst and solvent(Fig. 1). N-Aminotriazolethione Azomethine derivatives were obtained in excellent yields andshort times. Chemical structure of all molecules was characterized by their spectral data andelemental analyses.