Formulation and in-vitro evaluation of atorvastatin nanogel for topical drug delivery

Introduction and background :nanogel is cross-linked colloidal particles prepared from polymers network physically or chemically cross-linked, to provide controlled release and local delivery of therapeutic agents. nanogel of atorvastatin can deliver nanoparticles of drug to the wounds directly, better performance in solubility and reduce the associated side-effects and total drug dose. In this formulation we use biodegradable and biocompatible polymers such as chitosan and PVA. This polymers play role in wound healing.Material and Methods :Atorvastatin nanoparticles are prepared by antisolvent precipitation method. Ethanol and water were selected as solvent and antisolvent. PVA and chitosan were used as hydrophilic and hydrophobic polymers. Tween-80 was selected as a surfactant to inhibit the particle growth. We used herbal oil to improve the penetration efficacy of the nanogel into stratum corneum. then we prepared atorvastatin-encapsulated core-shell type nanoparticles. The particle size of atorvastatin nanoparticles was around 150 nm and the morphology was spherical shapes.Results :In this study, atorvastatin nanogel was successfully prepared and we showed that atorvastatin nanogel exert positive effects through their antimicrobial properties and antimicrobial activity. Methicillin-sensitive staphylococcus aureus (MSSA), methicillin-resistant staphylococcus aureus (MRSA), staphylococcus epidermidis were sensitive to atorvastatin nanoparticles.Conclusion :these results have given insight into the actions of atorvastatinnanoparticles and have provided a novel therapeutic direction for wound treatment in clinical practice. we state that atorvastatin nanogel have beneficial effects when used as a topical agent and Local atorvastatin therapy may be useful for healing the wounds. Further clinical and experimental studies are needed to confirm these results.

Keywords:

Atorvastatin nanoparticles , nanogel , nanoparticle , drug delivery