Publisher of Iranian Journals and Conference Proceedings

Please waite ..
Publisher of Iranian Journals and Conference Proceedings
Login |Register |Help |عضویت کتابخانه ها
Paper
Title

Preparation and antioxidant evaluation of chitosan hydrogel loaded with selenium nanoparticle in spinal cord injury-induced rat

Year: 1399
COI: ICNNA01_144
Language: EnglishView: 189
This Paper With 5 Page And PDF Format Ready To Download
محتوای کامل این Paper با فرمت WORD هم قابل دریافت می باشد.

Buy and Download

با استفاده از پرداخت اینترنتی بسیار سریع و ساده می توانید اصل این Paper را که دارای 5 صفحه است به صورت فایل PDF و یا WORD در اختیار داشته باشید.
آدرس ایمیل خود را در کادر زیر وارد نمایید:

Authors

Marzieh Sadeghi - Surgery Section in Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahrekord University of Sciences, Shahrekord, Iran
Pegah Khosravian - Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
Moosa javdani - Surgery Section in Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahrekord University of Sciences, Shahrekord, Iran

Abstract:

Traumatic spinal cord injury (SCI) is one of the major injuries to the central nervous system. The progressive wave of secondary injury in SCI is the leading cause of complications in patients with spinal cord injury. Oxidative stress is considered one of the hallmarks of the secondary phase of SCI and can therefore reduce oxidative stress by enhancing a number of cellular antioxidants such as superoxide dismutase, glutathione peroxidase, and catalase with antioxidants. Therefore, the design and topical application of chitosan hydrogel-loaded control-release drug delivery system with selenium nanoparticles in rats with spinal cord injury and evaluation of antioxidant changes in nerve tissue was considered as the aim of the present study. The activity of some antioxidant enzymes was measured in the spinal cord tissue. The results showed that malondialdehyde changes in all three groups were significantly increased after spinal cord injury, and these alternations were greater on days 3 and 7 postoperatively due to peroxidation in the control group compared to the other groups. However, administration of chitosan hydrogel alone and chitosan hydrogel loaded with selenium nanoparticles had no significant effect on glutathione peroxidase activity. There was no significant difference between the three groups in the level of catalase activity. Superoxide dismutase activity increased in all groups; but this increase was significantly greater in the positive and treatment control groups than in the negative control group.

Keywords:

Paper COI Code

This Paper COI Code is ICNNA01_144. Also You can use the following address to link to this article. This link is permanent and is used as an article registration confirmation in the Civilica reference:

https://civilica.com/doc/1141052/

How to Cite to This Paper:

If you want to refer to this Paper in your research work, you can simply use the following phrase in the resources section:
Sadeghi, Marzieh and Khosravian, Pegah and javdani, Moosa,1399,Preparation and antioxidant evaluation of chitosan hydrogel loaded with selenium nanoparticle in spinal cord injury-induced rat,International Conference on Nanotechnologu & Nanoscience,Tehran,https://civilica.com/doc/1141052

Research Info Management

Certificate | Report | من نویسنده این مقاله هستم

اطلاعات استنادی این Paper را به نرم افزارهای مدیریت اطلاعات علمی و استنادی ارسال نمایید و در تحقیقات خود از آن استفاده نمایید.

Scientometrics

The specifications of the publisher center of this Paper are as follows:
Type of center: دانشگاه دولتی
Paper count: 8,173
In the scientometrics section of CIVILICA, you can see the scientific ranking of the Iranian academic and research centers based on the statistics of indexed articles.

New Papers

New Researchs

Share this page

More information about COI

COI stands for "CIVILICA Object Identifier". COI is the unique code assigned to articles of Iranian conferences and journals when indexing on the CIVILICA citation database.

The COI is the national code of documents indexed in CIVILICA and is a unique and permanent code. it can always be cited and tracked and assumed as registration confirmation ID.

Support