Differential DNA methylation and gene expression analyses of stage one Papillary Thyroid Carcinoma revealed potential biomarkers associated with cancer initiation

The incidence of thyroid cancer has been increased worldwide during the past decades .According to Globocan 2018, thyroid cancer is in the 9th place for incidence with 567 ,000 cases worldwide. Papillary thyroid carcinoma (PTC) is the most frequent histotype, comprising 85 –90 %of all thyroid cases. Identification of gene expression regulators that can be used as prognostic/predictive biomarkers in primary stage of PTC could help to early detection of this malignancy, leading to more efficient management outcomes. DNA methylation which results in gene silencing is one of the major mechanisms of epigenetic regulation of expression. The main objective this study was to valuate the correlation between changes in DNA methylation pattern and gene expression alterations in stage I of PTC, which could partly unravel the underlying molecular changes involved in initiation.