Comparing the Effects of Vacuum Constrictive Devices and Intra-Cavernosal Injection of Papaverine for Erectile Dysfunction Treatment

Introduction: For erectile dysfunction (ED) treatment, Vacuum therapy (VT) utilizes negative pressure to distend the corporal sinusoids and to increase the blood inflow to the penis. In the current study, we evaluated the vacuum constrictive device (VCD) and intracavernosal injection (ICI) of papaverine for the treatment of ED. Methods: A total number of ۸۰ erectile dysfunctions (ED) were divided into ۴ groups of ۲۰ couples. The first group was treated with Papaverine who had a virgin wife (a). The second group was unconsummated marriage couples who were treated with vacuums (b). The third group was and the couples with experience of sexual intercourse who had been treated with Papaverine injection (c). The fourth group was the couples with experience of sexual intercourse that were treated with a vacuum device (d). Results: After ۴ months of treatment, all patients were able to have sex. In the unconsummated couples group treated with papaverine and consummated couples treated with papaverine, all of the indicators of the erectile function were significantly increased compared to pre-treatment (p-value<۰/۰۵). There were no significant differences between the two methods in terms of other complications such as ecchymosis, blisters, headache, cutaneous rash, and vaso-vascular shock (p-value>۰/۰۵). Conclusions: This study showed that in patients with erectile dysfunction who are having virgin spouses and who are not responding to the first line of oral medication that ۵-inhibitors phosphodiesterase can be the excellent candidate for ICI of vasoactive drugs therapy.

Keywords:

Erectile Dysfunction , Papaverine , Vacuum constrictive device , Intra-cavernosal injection