Investigating the Response of Lipid Profile, Insulin Resistance and Mitochondrial Biogenesis of Obese Rats to Various Training

Background and Objective: The aim of this study was to investigate the response of lipid profile, insulin resistance, and mitochondrial biogenesis index of obese rats to various exercise training. Material and Methods: 24 rats were randomly divided into four groups of 6: 1) obese-interval training (HIIT); 2) obese-continuous training (CT); 3) obese control (OB) and 4) control (Cont). During the study period, (from 16 to 24 weeks) rats in groups 1, 2, and 3 were given high-fat foods (from 16 to 24 weeks). After being familiarized, rats in groups 1 and 2 performed HIIT and continuous training three times a week for eight weeks, respectively. Data were analyzed with one-way ANOVA and Bonferroni posthoc test (p≤0.05). Results: A study of Western blotting showed that the amount of muscle PGC1α in HIIT and CT groups was significantly higher than OB and Cont groups. Also, despite the more reduction in visceral fat and other factors in the CT group, the HIIT groupchr(chr('39')39chr('39'))s PGC1α content was higher than the CT group, which was not significant. Serum levels of glucose, insulin, and insulin resistance in HIIT and CT groups (At 24 weeks) were significantly lower than the OB group (p≤0.05); However, these glycemic indices weren’t significantly different from the control group (P≥0.05). There was a significant difference in TG, TC, LDL, and HDL values between the exercise groups with the OB group. In addition, the increase in visceral fat was 27% in the OB group, while a decrease of 30% and 43% was observed in the HIIT and CT groups, respectively (P<0.05). Conclusion: It seems that the use of HIIT can be as effective as continuous training on lipid profile, insulin resistance, and mitochondrial function of muscle tissue in obese people.

Investigating the Response of Lipid Profile, Insulin Resistance and Mitochondrial Biogenesis of Obese Rats to Various Training Keywords:

Obesity , Organelle Biogenesis , Exercise , Insulin Resistance