Synthesis of novel pyrrole derivatives from reaction among aldehydes , amines and α-ketoester using hetrogenous catalysis

New solid catalyst, consisting of sulfuric acid supported on amine functionalized polystyrene (PS-DETSO۳H) has been developed via immobilizing -SO۳H onto an amine-functionalized PS-DET surface. The prepared catalyst could be dispersed homogeneously in hexan and further used as a heterogeneous, reusable and efficient catalyst for the synthesis of ۱,۵-diaryl-۳-(arylamino)-۱H-pyrrol-۲(۵H)-one by reaction of aldehyde, amine and ethyl pyruvate in high yield and short time. These compounds have biological and pharmacological properties and are also used in medicinal chemistry.

Keywords:

Heterogeneous catalysts , pyrrol , aldehyde , amine.