Development of ۱۷۷Lu-phytate Complex for Radiosynovectomy

Publish Year: 1392
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IJBMS-16-5_008

تاریخ نمایه سازی: 4 آبان 1400

Abstract:

Objective(s): In this work a new possible agent for radiosynovectomy has been targeted for articular pain palliation. Materials and Methods: Lu-۱۷۷ of ۲.۶-۳ GBq/mg specific activity was obtained by irradiation of natural Lu۲O۳ sample with thermal neutron flux of ۴ × ۱۰۱۳ n.cm-۲.s-۱. The product was converted into chloride form which was further used for labeling of ۱۷۷Lu-phytate complex and checked using ITLC (MeOH: H۲O: acetic acid, ۴: ۴: ۲, as mobile phase). The complex stability and viscosity were checked in the final solution up to seven days. The prepared complex solution (۱۰۰ µCi/۱۰۰ µl) was injected intra-articularly to male rat knee joint. Leakage of radioactivity from injection site and its distribution in organs were investigated up to seven days. Results: The complex was successfully prepared with high radiochemical purity (>۹۹.۹ %). Approximately, the whole injected dose has remained in injection site seven days after injection. Conclusion: The complex was proved to be a feasible agent for cavital radiotherapy in oncology and rheumatology

Keywords:

Biodistribution Lutetium-۱۷۷ Phytate Radiosynovectomy

Authors

Hassan Yousefnia

Radiopharmaceutical Research and Development Lab, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran, P.O.Box:۱۴۳۹۵-۸۳۶ ۲ Faculty of Energy Engineering and Physics, Amirkabir University of Technology. Tehran, Iran

Amir Reza Jalilian

Radiopharmaceutical Research and Development Lab, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran, P.O.Box:۱۴۳۹۵-۸۳۶

Ali Bahrami-Samani

Radiopharmaceutical Research and Development Lab, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran, P.O.Box:۱۴۳۹۵-۸۳۶

Mohammad Mazidi

Radiopharmaceutical Research and Development Lab, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran, P.O.Box:۱۴۳۹۵-۸۳۶

Mohammad Ghannadi Maragheh۱

Radiopharmaceutical Research and Development Lab, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran, P.O.Box:۱۴۳۹۵-۸۳۶

Fereydoun Abbasi-Davani

Radiation Application Group, Faculty of Nuclear Engineering, Shahid Beheshti University, Tehran, Iran

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