Development of ۱۷۷Lu-phytate Complex for Radiosynovectomy

Objective(s): In this work a new possible agent for radiosynovectomy has been targeted for articular pain palliation. Materials and Methods: Lu-۱۷۷ of ۲.۶-۳ GBq/mg specific activity was obtained by irradiation of natural Lu۲O۳ sample with thermal neutron flux of ۴ × ۱۰۱۳ n.cm-۲.s-۱. The product was converted into chloride form which was further used for labeling of ۱۷۷Lu-phytate complex and checked using ITLC (MeOH: H۲O: acetic acid, ۴: ۴: ۲, as mobile phase). The complex stability and viscosity were checked in the final solution up to seven days. The prepared complex solution (۱۰۰ µCi/۱۰۰ µl) was injected intra-articularly to male rat knee joint. Leakage of radioactivity from injection site and its distribution in organs were investigated up to seven days. Results: The complex was successfully prepared with high radiochemical purity (>۹۹.۹ %). Approximately, the whole injected dose has remained in injection site seven days after injection. Conclusion: The complex was proved to be a feasible agent for cavital radiotherapy in oncology and rheumatology