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Effect of metformin on pregnancy outcome in healthy overweight pregnant women; a double-blinded parallel randomized clinical trial

Publish Year: 1400
Type: Conference paper
Language: English
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HSEBCNF04_039

Index date: 2 November 2021

Effect of metformin on pregnancy outcome in healthy overweight pregnant women; a double-blinded parallel randomized clinical trial abstract

Introduction: Maternal obesity increases the risk of pregnancy complications such as preeclampsia, postpartum hemorrhage, weight gain at birth and the need for cesarean section. Interventions that can help prevent fetal macrosomia and its adverse metabolic effects during pregnancy seem to help improve the lives of neonate in future.Objectives: Recently, the role of hyperglycemia and insulin resistance has been cited as factors that lead to increased maternal weight gain during pregnancy and fetal macrosomia and gestational diabetes. And in this study, we studied the role of metformin in overweight of mothers.Patients and Methods: 360 pregnant women at 12-16 weeks of pregnancy referred to the gynecology clinic of Motahhari hospital in Urmia were randomly assigned to the two groups of 180 individuals. The intervention group was given 1000 mg of metformin and the control group was given placebo. Demographic characteristics of patients such as age, gravidity, parity, preterm infant weight, live birth, abortion, previous delivery method, maternal weight, BMI, birth weight, delivery method, blood sugar at birth, hospitalization rate in NICU, gestational age at birth, neonatal hypoglycemia, infant mortality and anomalies were also recorded. The results were analyzed and evaluated with SPSS 21.Results: Out of 180 patients, 169 patients remained in the intervention group and 171 patients remained in the control group. The demographic characteristics of the mothers were the same in the both groups. In the control group, 12 people (7%) and in the intervention group, 11 people (6.5%) had gestational diabetes (P=0.8). In the control group, 13 infants (7.6%) and in the intervention group, 12 infants (7.1%) had a birth weight more than 4,000 g (P=0.8). In the control group, 13 patients (7.6%) and in the intervention group, 5 patients (2.9%) had maternal preeclampsia and increased blood pressure during pregnancy (P= 0.053). In the control group, the mean weighting of mothers was 10.22 ± 3.3 kg and in the intervention group were 7.6 ± 2.3 kg during pregnancy (P <0.001).Conclusion: The use of metformin has been shown to be effective in controlling overweight in overweight mothers, but has not affected the birth weight of infants. Metformin has not had an effect on pregnancy results.

Effect of metformin on pregnancy outcome in healthy overweight pregnant women; a double-blinded parallel randomized clinical trial Keywords:

Effect of metformin on pregnancy outcome in healthy overweight pregnant women; a double-blinded parallel randomized clinical trial authors

Shabnam Vazifekhah

Urmia University of Medical Sciences, Urmia, Iran

Samira Esmaieli

Urmia University of Medical Sciences, Urmia, Iran

Javad Rasuoli

Urmia University of Medical Sciences, Urmia, Iran