Antibacterial Activity of New Compounds Based on Nanocomposites

Background: Antimicrobial resistance is a major problem in treatment and public health, and it has beenincreasing over the last few decades. Hence, serious measurements are needed to overcome this challenge.In this study, we evaluated antibacterial and antifungal activity of some nanocomposites including titaniumdioxide (۵a), polyimide nanocomposites containing cerium oxide (۵b), silver-titanium dioxide nanoparticlesprepared under desired conditions (۵c), polyaniline/wheat husk ash PANI /WHA (۵d), Ag-TiO۲ prepared bysol–gel route (۵e), and cellulose-graphene (۵f) against some bacterial and fungal strains, which are the mostcommon agents in many infectious diseases.Methods: The nanoparticles were prepared in desired condition. The agar dilution and well agar diffusionmethods were used for determination of inhibition zoon and minimum inhibitory concentration (MIC) duringpreliminary evaluation of antimicrobial activity against Staphylococcus aureus, Streptococcus pyogenes,Pseudomonas aeruginosa, Escherichia coli and Candida albicans.Results: The results showed that the nanocomposites had good activity against gram-negative bacteria.Conclusions: Our results showed that the inhibitory activity of these nanocomposites on gram-negative bacteriawas better than gram-positive bacteria.

Keywords:

Antimicrobial activity , Nanocomposite , Silver-titanium dioxide , Polyimide , Cellulose-graphene