The MostWell - known Markers of CSCs and Their Role in Growth of Tumors, Drug Resistance and Metastasis
Publish place: Human Genetics and Genomics، Vol: 2، Issue: 1
Publish Year: 1396
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JHGG-2-1_001
تاریخ نمایه سازی: 30 مرداد 1401
Abstract:
The capability of cancer cells including tumor initiation, maintenance, and extension is associated with cancer stem cells. The substantialfeatures of CSCs are self - renewal and pluripotency. Therapeutic resistance of CSCs can result in cancer recurrence andfailure of cancer treatment. Isolation and characterization of CSCs are required for targeted cancer therapies. CSCs can be distinguishedand separated by surface markers. In this review, after definition of CSC hypothesis, different markers of CSC are introduced.The information about CSC markers provides promise for better isolation and more effective CSC-targeting therapeutic in future.
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Authors
Mohammad Javad Dehghan Esmatabadi
Malek - Ashtar University of Technology, Tehran, Iran
Fatemeh Movahedi Motlagh
Cellular and Molecular Research Center, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran- Department of Medical Genetics, Tehran University of Medical Sciences, Tehran, Iran
Azadeh Etemadzadeh
Institute of Medical Biotechnology, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
Samira Hajigholami
Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran