Metaplastic Breast Cancer with Chondroid Differentiation

Background: Metaplastic breast cancer (MBC) cancer is a rare subtype ofbreast carcinoma and carries a worse prognosis. Chondroid differentiation is therarest among all its histologic subtypes. We report a case of MBC with chondroiddifferentiation and review its clinicopathological details, genetic basis, andmanagement.Case presentation: A ۵۶-year female presented with right-sided large breastlump. She noticed this lump ۴ months before presenting. Trucut biopsy wassuggestive of invasive ductal carcinoma. She underwent breast conservationsurgery and histology was consistent with MBC with chondroid differentiation,pT۲N۳aM۰. Tumour was triple-negative for ER, PR, and Her-۲- neu receptors.Adjuvant treatment with chemotherapy followed by radiotherapy was given andshe has been doing fine during ۱۱ months of follow-up.Conclusion: The MBC is an uncommon subtype with heterogeneity inbiological and morphological features and its knowledge is paramount whileevaluating a breast lump. Understanding the pathologic and molecular basis isimperative in developing the targeted therapy to improve outcomes.

Keywords:

Metaplastic breast cancer , chondroid differentiation , triple negative breast cancer