Deciphering the Impact of the L۸۵۸R Mutation in EGFR: Computational Insights and Therapeutic Implications in Non-Small-Cell Lung Cancer

Publish Year: 1402
نوع سند: مقاله کنفرانسی
زبان: English
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تاریخ نمایه سازی: 13 اسفند 1402

Abstract:

This study delves into the L۸۵۸R mutation in the Epidermal Growth Factor Receptor (EGFR) and its impact on lung cancer, specifically non-small-cell lung cancer (NSCLC). Employing computational tools like the DynaMut web server and PSIPRED, we assessed evolutionary conservation, protein stability, flexibility, secondary structure, and interatomic interactions of the EGFR protein. Our findings suggest that the L۸۵۸R mutation, while highly conserved, induces significant changes in the protein's stability, flexibility, and secondary structure, potentially influencing its function. These alterations offer insights into the development of targeted therapies for NSCLC, underscoring the mutation's impact on protein behavior and therapeutic implications. The study highlights the importance of computational predictions in understanding the molecular basis of cancer and suggests the need for experimental validation in future research.

Authors

Seyedeh Yasaman Mousavi

Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran

Mousavi Jafari

Department of Medical microbiology and virology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran