Health-promoting properties of vitamin C and omega-3 fatty acids in hemodialysis children abstract
Reported clinical findings indicate that omega-3 fatty acids (eicosatetraenoic acid (EPA) and docosahexaenoicacid (DHA)) have anti-inflammatory and cardioprotective properties. In addition, vitamin C is a powerfulantioxidant that is thought to save you from low-density lipoprotein (LDL) oxidation. As, free radical damagebegins early in
chronic kidney disease (CKD) progression and it is an important risk factor for increasedinflammatory status, CVD and its mortality, this study investigates the antioxidant impact of
Vitamin C andOmega-3 in
hemodialysis (HD).Material and MethodsTo accomplish this narrative review, we searched 4 Databases (PubMed, Web of Science, Scopus and googlescholar) based on the search strategy from 2010 to 2022 with the high sensitivity on September 2022 by followingMeSH keywords: "
Vitamin C ", "
Omega-3 ", "
cardiovascular disease ", "
chronic kidney disease ", "Hemodialysis ".FindingsMost research indicates that omega-3 fatty acids could act as an antioxidant rather than a pro-oxidant in severalcells, including vascular cells, diminishing inflammation, oxidative stress, and, in turn, the risk of atherosclerosisand degenerative disorders such as cardiovascular disease. Based on experiments and investigations scorbate actsthrough reducing other molecules, mostly transition-metal ions like ferric iron (Fe3+) and copper, either at theactive site of enzymes or as free ions. Furthermore, In the presence of transition metals like iron, pro-oxidanteffects might result in an extra oxi- dative damage, and ascorbylation might contribute to the carbonyl stress.Some research reported administration of 250 mg/day of intravenous (IV) vitamin C after HD sessions 3 times aweek for 12 weeks and total DHA 600 mg and total EPA 1800 mg three times a week during dialysis treatment.ConclusionCurrent data indicate that vitamin C and omega-3 have the potential to prevent CVD in children with HD.