The Effect of Silk-nanocefixime Suture on Healing and Antibacterial Properties
Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JKMU-29-3_004
تاریخ نمایه سازی: 19 دی 1401
Abstract:
Background: Surgical sutures are sterile filaments to support the healing process. Also Suture as a major part of surgical site management can challenge surgical wound healing. The objective of the current study was to prevent surgical site infection by creating a new antibacterial silk-nano cefixime suture.Methods: The silk suture became silk-nano cefixime suture by immersing in the ۱, ۲, and ۳ wt % cefixime solutions. The antibacterial activity of silk-nano cefixime suture was tested on E. coli (ATCC۲۵۹۲۲). The healing effect of silk-nano cefixime suture was evaluated by H&E staining sections and compared between the control and treated groups on days ۳, ۸ and ۱۴. The obtained quantitative data were presented as mean ± standard deviation. In order to compare the mean of quantitative variables between the studied groups, general linear model of statistical analysis test and ۳-D SPSS charts were used (P ≤ ۰.۰۵).Results: The inhibition zone diameter of E. coli (ATCC۲۵۹۲۲) was ۲۵ mm and no statistically significant difference was found between the healing properties (P≥.۰۵). There was a significant difference in the mean of Polymorphonuclear leukocytes (PMN) and macrophage infiltration between the control and treated groups on day ۸ (p≤ ۰.۰۵).Conclusion: Our data indicate that silk-nano cefixime suture has the potential to reduce the risk of surgical site infections. Finally, it is strongly recommended to introduce silk-nano cefixime suture as a reliable substitute for current surgical sutures.
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Authors
Ali Alirezaie Alavijeh
Clinical Department, Shahrekord University, Shahrekord, Iran
Masoomeh Dadpay
Department of Pathology, Medical Faculty, AJA University of Medical Sciences, Tehran, Iran
Mohammad Barati
Department of Applied Chemistry, Faculty of Chemistry, University of Kashan, Kashan, Iran
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