The Relationship Between Positive Cultures With Multidrug-Resistant Microorganisms and Mortality in a General Intensive Care Unit
Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JCMI-9-2_003
تاریخ نمایه سازی: 28 تیر 1402
Abstract:
Aim: The patients in the intensive care unit (ICU) are more susceptible to healthcare-associated infections
(HAI). Higher rates of nosocomial infections in ICU patients are associated with higher morbidity, mortality,
and costs. The primary outcome of our study was to investigate the relationship between antibiotic
resistance and mortality in ICU patients, and the secondary outcome was to evaluate the relationship
between antibiotic resistance and the length of ICU or hospital stay.
Methods: A ۵-year observational retrospective study was conducted on patients in the ICU of Hasheminejad
Kidney Center affiliated with Iran University of Medical Sciences, Tehran, Iran from January ۱, ۲۰۱۵, to
January ۱, ۲۰۲۰. The data related to age, gender, admission type, comorbidities, length of ICU stay, length
of hospital stay, infection source, microorganism type, and resistance pattern of all isolates and outcomes
were collected based on the study purpose.
Results: During the ۵-year study, ۲۸۹۹ patients were admitted to the ICU, but only ۷۴۷ patients were
enrolled in the study, including ۴۲۶ males (۵۷%). The median age was ۶۵ years (۱۹-۹۷ years). The mean
length of ICU stay was greater in culture-positive patients (۸.۴۲ vs. ۳.۵ days, P > ۰.۰۰۱). Culture-positive
patients had significantly higher mortality compared to culture-negative patients (۶۳.۸% vs. ۳۶.۲%,
P > ۰.۰۰۱). In our study, it was found that resistant microorganisms have increased mortality by ۲.۶ times
in the ICU in the crude model (OR: ۲.۶, P > ۰.۰۰۱).
Conclusion: The findings of our study suggest that multidrug-resistant pathogens increase ICU stay and
mortality.
Keywords:
Authors
Bahareh Marghoob
Department of Nephrology, Hasheminejad Kidney Center, Iran University of Medical Sciences, Tehran, Iran
Malihe Khosravi-Khezri
Department of Clinical Pharmacy, Hasheminejad Kidney Center, Iran University of Medical Sciences, Tehran, Iran