Determination of Dosimetric Parameters of the Second Model of Pd-۱۰۳ Seed Manufactured at Agricultural, Medical and Industrial Research School

Introduction: The use of low energy isotopes such as  ۱۰۳ Pd in brachytherapy for the treatment of cancers  such as prostate, eye, head, neck, breast and cervix is increasing. In this regard, different models of Pd- ۱۰۳  seeds  have  been  designed  and  manufactured  at  the  Agricultural,  Medical  and  Industrial  Research  School (AMIRS) of Atomic Energy Organization of Iran. In this research, the dosimetric parameters of  the second model of Pd-۱۰۳ seed manufactured at AMIRS have been calculated and measured.   Materials and Methods: The dosimetric parameters of the second Pd-۱۰۳ seed manufactured at AMIRS  were determined according to TG-۴۳U۱ protocol using Monte Carlo calculations (MCNP۴C computer  code)  and  measurements  performed  using  TLD-GR۲۰۰A  dosimeters  in  a  Perspex  phantom.  The  parameters  include  dose  rate  constant,  geometry  function,  radial  dose  function,  anisotropy  function,  anisotropy factor and anisotropy constant.  Results:  It  was  found  that  by  using  MCNP۴C  code  the  calculated  dose  rate  constant  in  water  and  Perspex  was  ۰.۷۰۶±۰.۰۰۱   and  ۰.۵۰۱±۰.۰۰۱  cGyh -۱ U -۱ , respectively.  Using  the  calculated  geometry  function,  the  radial  dose  function  and  the  anisotropy  function  were  determined  by  experimental  and  theoretical methods in water and Perspex phantom. Also, the calculated value of anisotropy constant in  water was equal to ۰.۸۸.  Discussion and Conclusion: A discrepancy of less than ۱۰% between the calculated and the measured  values indicates a reasonable agreement between the simulation and the measurement method. Also, the  dosimetric parameters of this seed have been compared to the dosimetric parameters of the first Pd-۱۰۳  seed  manufactured  at  AMIRS  and  some  other  seeds.  The  obtained  results  indicate  that  the  seeds  manufactured at AMIRS have acceptable dosimetric parameters suitable for brachytherapy applications.

Keywords:

Brachytherapy , Pd-۱۰۳ Seed , TG-۴۳U۱ Protocol , Monte Carlo Simulation , Thermoluminescent Dosimetry