A Comparative Study of Treatment of Hypericum perforatum and Vitamin B۶ for Mastalgi: Clinical Trial

This study aimed to investigate the effect of vitamin B۶ and Hypericum perforatum as a treatment for mastalgia. The double-blind randomized controlled trial (RCT) was conducted on ۲۳۸ patients with premenstrual syndrome referred to gynecology clinic of Zeinabieh Hospital of Shiraz. Two months before the intervention, all patients completed a prospective menstrual daily questionnaire. The participants were randomized into three groups: I (receiving two tablets of H. perforatum containing ۳۳۰µg of hypericin), II (receiving two tablets of containing ۸۰ mg of vit B۶) and III (receiving placebo), which were treated daily from the first to ۳۰th day of menstrual cycle for two cycles. Pain intensity was assessed with a visual analogue scale. Data analyzed by SPSS-۲۱. There was no significant difference in the mean age, weight and height between groups. The results showed that the studied groups had different behaviors with mutual effect at different times. The results of mastalgia severity changes were significant between groups, that showed the pattern of time changes of the groups was significantly different from each other (p=۰.۰۴۸). While vit B۶ was more effective than placebo in relieving mastalgia (P<۰.۰۰۱), the difference between H. perforatum and placebo was not statistically significant (P = ۰.۱۶). H. perforatum showed no significant effect on mastalgia.Some factors such as affordability, availability and side effects should be considered to select the right candidate. Given the importance of providing women's health and that mastalgia can disrupt their activities, vit B۶ can be prescribed as a useful way to relieve cyclic mastalgia.

Keywords:

Cyclic mastalgia , Hypericum perforatum , Vitamin B۶