The Investigation of Prophylactic Effect of StrataXRT Gel on Radiation-Induced Dermatitis in Breast Cancer Patients: A Randomized Clinical Trial

Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_MISJ-13-2_010

تاریخ نمایه سازی: 25 آبان 1402

Abstract:

Background: Breast cancer is among the most prevalent cancers in women. Radiotherapy is an important part in treatment of breast cancer, associated with some side-effects, including skin dermatitis. Dermatitis may be severe and impair quality of life. Multiple agents have been studied, but no standard treatment is yet available. Silicone based gel (StrataXRT) was promising in some studies in reducing skin inflammation and also radiotherapy-induced dermatitis.Method: This was a randomized trial on ۱۰۰ women with breast cancer who had undergone quadrantectomy for breast cancer. They received StrataXRT gel or best supportive care during radiotherapy. Dermatitis area and grade of dermatitis were measured.Results: Regarding the mean size of radiation-induced dermatitis area, there was a significant difference between the intervention (۳۶.۸۸ cm۲ ± ۶۹.۹۳) and control (۸۳.۸۳ cm۲ ± ۷۹.۳۴) groups (P = ۰.۰۰۲). During radiotherapy, except in the fourth week, dermatitis was significantly more severe in the control group.Conclusion: It seems that StrataXRT is helpful in decreasing radiotherapy-induced dermatitis.

Authors

Shapour Omidvari

Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Zahra Eskandari

Radiation Oncology Department, Shiraz University of Medical Sciences, Shiraz, Iran

Hamid Nasrollahi

Radiation Oncology Department, Shiraz University of Medical Sciences, Shiraz, Iran

Niloofar Ahmadloo

Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Mansour Ansari

Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Seyed Hassan Hamedi

Radiation Oncology Department, Shiraz University of Medical Sciences, Shiraz, Iran

Nezhat Khanjani

Radiation Oncology Department, Shiraz University of Medical Sciences, Shiraz, Iran

Behnam Kadkhodaei

Radiation Oncology Department, Shiraz University of Medical Sciences, Shiraz, Iran

Ahmad Mosalaei

Radiation Oncology Department, Shiraz University of Medical Sciences, Shiraz, Iran

Mohammad Mohammadianpanah

Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

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