Investigating Kidney Pathologic Events in Nude Mice with Human Metastatic Breast Cancer

Introduction: Human metastatic breast adenocarcinoma is one of the most diagnosed cancers in females which can metastasize to other organs such as kidneys. So, we investigated the possible renal parenchymal changes in nude mice due to induced metastatic breast adenocarcinoma.Methods: ۸ female mice were randomized into ۲ groups. MDA-MB-۲۳۱ subtype was injected in their left flank in the second group. Weight and tumor size were measured weekly. After euthanasia, tumoral and renal tissues were assessed by a pathologist.Results: The mean weight of the removed tumors was ۲.۰۴ grams (±۰.۰۵). Also, the mean weight of kidneys in G۱ was ۲.۸±۰.۰۷ grams, and in G۲ was ۲.۷۱±۰.۰۹ grams (P-value<۰.۰۵). Histopathological sections of renal parenchyma demonstrate normal and injured structures of the kidney tissue in groups ۱ and ۲, respectively. The thin arrow indicates the edema and the arrow head shows the hyperemia.Conclusion: There seems to be no statistically meaningful difference in renal changes and weight gain between normal and xenograft groups, but every ۴ weeks’ measures show the tumor group a bit higher. There was no difference in metastasis pattern in both groups.

Keywords:

Metastatic breast cancer , Renal , MDA-MB-۲۳۱ , BALB/c Nude Mice