Expression levels of miR-۲۲, miR-۳۰c, miR-۱۴۵, and miR-۵۱۹d and their possible associations with inflammatory markers among patients with coronary artery disease

Saied Ghorbani; Seyed Hashem Sezavar; Farah Bokharaei-Salim; Angila Ataei-Pirkooh; Ahmad Tavakoli; Davod Javanmard; Javid Sadri-Nahand; Seyed Jalal Kiani; Hadi Ghaffari; Leila Beikzadeh; Latif Hamidpoor; Seyed Hamidreza Monavari

Expression levels of miR-22, miR-30c, miR-145, and miR-519d and their possible associations with inflammatory markers among patients with coronary artery disease

Publish place: ARYA Atherosclerosis، Vol: 18، Issue: 3

Publish Year: 1401

Type: Journal paper

Language: English

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https://civilica.com/doc/1873037

Document National Code:

JR_RYA-18-3_010

Index date: 1 January 2024

Expression levels of miR-22, miR-30c, miR-145, and miR-519d and their possible associations with inflammatory markers among patients with coronary artery disease abstract

BACKGROUND: Coronary artery disease (CAD) is a leading cause of death around the world. Micro-ribonucleic acid (miRNA) can be involved in forming of atherosclerotic plaques, inflammation, cholesterol metabolism, and other mechanisms involved in CAD development. This study aimed to evaluate the expression level of miR-22, miR-30c, miR-145, and miR-519d and their possible association with inflammatory markers among patients with CAD.METHODS: The expression level of miR-22, miR-30c, miR-145, miR-519d, interleukin 6 (IL-6), and transforming growth factor beta (TGF-β) was determined in peripheral blood mononuclear cells (PBMCs) from 46 patients with CAD and 39 healthy controls using real-time quantitative polymerase chain reaction (qPCR) assay.RESULTS: 53.8% (n = 21) and 52.2% (n = 24) of controls and cases were men, respectively; the mean age was 59.8 ± 7.4 and 57.0 ± 9.8 years, respectively. The miRNA expression pattern of each group showed significantly different expression profiles. In the CAD patients group, miR-22, miR-30c, and miR-145 were down-regulated compared to the control group. On the opposite, miR-519d was up-regulated in patients with CAD compared to the control group. Our results also showed that the expression levels of IL-6 and TGF-β were up-regulated among patients with CAD compared to the control group. In addition, the expression of miR-145 and miR-519d had a significantly negative and positive correlation with TGF-β and IL-6, respectively.CONCLUSION: The change in expression levels of miR-22, miR-30c, miR-145, and miR-519d in PBMCs of patients with CAD could be considered as a potential biomarker for CAD.

Expression levels of miR-22, miR-30c, miR-145, and miR-519d and their possible associations with inflammatory markers among patients with coronary artery disease Keywords:

Coronary Artery Diseases , miRNAs , Peripheral blood mononuclear cell

Expression levels of miR-22, miR-30c, miR-145, and miR-519d and their possible associations with inflammatory markers among patients with coronary artery disease authors

Saied Ghorbani

Department of Medical Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Seyed Hashem Sezavar

Department of Cardiology, School of Medicine AND Research Center for Prevention of Cardiovascular Endocrinology and Metabolism, Research Institute Hazrat-e Rasool General Hospital, Iran University of Medical Sciences, Tehran, Iran

Farah Bokharaei-Salim

Department of Medical Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Angila Ataei-Pirkooh

Department of Medical Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Ahmad Tavakoli

Department of Virology, School of Medicine AND Research Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran

Davod Javanmard

Infectious Disease Research Center, Birjand University of Medical Sciences, Birjand, Iran

Javid Sadri-Nahand

Department of Medical Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Seyed Jalal Kiani

Department of Medical Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Hadi Ghaffari

Department of Bacteriology and Virology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran

Leila Beikzadeh

Department of Medical Laboratory Sciences, School of Paramedicine, Alborz University of Medical Sciences, Karaj, Iran

Latif Hamidpoor

Iranian Blood Transfusion Organization, Tehran, Iran

Seyed Hamidreza Monavari

Department of Medical Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

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