Bovine Leukaemia Virus Tax Antigen Identification in Human Lymphoma Tissue: Possibility of onco-protein Gene Ttransmission
Publish place: Research in Molecular Medicine، Vol: 7، Issue: 2
Publish Year: 1398
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_REMJ-7-2_004
تاریخ نمایه سازی: 22 دی 1402
Abstract:
Background: Bovine leukaemia virus (BLV) is the cause of enzootic bovine leukaemia which belongs to retroviruses including Human T-cell leukaemia virus and simian T-lymphotropic virus. Due to this familiarity, the possibility of virus (BLV) transfer from animal production to humans may exist.
Materials and methods: In the present study, formalin-fixed, paraffin-embedded and fresh human lymphomas tissues were used for detecting the BLV Tax genome and BLV Tax expression using nested-PCR and RT-nested-PCR.
Results: Nested-PCR evaluation showed that ۹ of ۴۱ samples contained Tax region of BLV genome, of which eight samples belonged to high grade diffuse large cell lymphoma (B-cell type). Also, the results of RT-nested-PCR showed the BLV Tax expression in ۲ of ۵ high grade diffuse large cell lymphoma (B-cell type) samples.
Conclusion: These findings explain the possible relation between BLV infection and the occurrence of some types of human lymphomas for the first time.
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Authors
Camellia Taghadosi
Graduated student, Faculty of Veterinary Medicine, Shahrekord university, Shahrekord, Iran.
Gholamali Kojouri
Professor, Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahrekord university
Alimohammad Ahadi
Assistant Professor, Department of Genetic, Faculty of Basic Sciences, Shahrekord University, Shahrekord, Iran.
Mohammad Hashemi Bahremani
Associate Professor, Laboratory of Pathology, Emam Hosein Hospital, Tehran, Iran.
Abdolnabi Kojouri
Faculty of Medicine, International Campus of Shahid Sadoughi Medical University, Yazd, Iran
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