Quercetin may reduce the risk of developing the symptoms of COVID-۱۹

Objective: Recent evidence reported that some dietary compounds like quercetin and apigenin as the most well-known flavonoids with anti-inflammatory effects may inhibit SARS-CoV-۲ main protease. The hypothesis of the promising effects and possible mechanisms of action of quercetin against COVID-۱۹ were assessed in this article.Materials and Methods: Related papers on the inhibitory effects of quercetin against COVID-۱۹ were collected using the following search strategy: “corona or coronavirus or COVID or COVID-۱۹ or viral or virus” AND “nutrient or flavonoid or Quercetin”.Results: The findings indicated that quercetin can be considered an effective agent against COVID-۱۹ because of its SARS-CoV-۲ main protease and RNA-dependent RNA polymerase inhibitory effects. In addition, quercetin may attenuate angiotensin-converting enzyme-۲ (ACE-۲) receptors leading to a reduction of SARS-CoV-۲ ability to enter host cells. Moreover, the antiviral, anti-inflammatory, and immunomodulatory activities of quercetin have been frequently reported.Conclusion: Quercetin may be an effective agent for managing the complications of COVID-۱۹. Further longitudinal human studies are warranted.

Keywords:

COVID-۱۹ , SARS-CoV-۲ main protease , ACE-۲ receptors , RNA-dependent RNA polymerase , Quercetin