Histomorphometric and stereological study of testicular tissue in diabetic rats following lead acetate and cinnamon treatment

Uncontrollable acute and chronic diabetes endangers people's quality of life in both developed and underdeveloped countries. Therefore, it appears crucial to investigate diabetes and its management strategies. Following the growth of environmental contaminants such as lead, we are seeing a rise in physical illnesses. Lead is absorbed and carried into the circulatory system, where it binds to the hemoglobin of red blood cells and accessing the tissues. The utilization of herbal plants therapy is growing nowadays. Cinnamon has a significant influence in neutralizing free radicals due to its numerous antioxidant capabilities, consequently the main objective of the above study was to evaluate the antioxidant effects of cinnamon against the oxidative stress of lead acetate on alloxan-induced diabetic rats. ۲۴ male Wistar-albino rats were selected and slaughtered after the treatment period in accordance with animal welfare guidelines. Following sample preparation, the prepared slides were inspected and the data were analyzed using SPSS software. Histomorphometrical evaluations indicated an increase in the number and area of seminiferous tubules in the diabetic and lead acetate-treated diabetic group following cinnamon administration. Furthermore, surface evaluating examinations indicated that cinnamon treatment increased the area of the seminiferous tubules while decreasing the area of the interstitial parenchyma in the diabetic group and the lead acetate-treated diabetic group.

Keywords:

cinnamon , Histomorphometry , lead acetate , stereology , testis