Combined Effect of Swimming Training and Arbutin Supplementation on Kidney Total Oxidant and Antioxidant Status in Alloxan-induced Diabetic Rats

Objective: Diabetes is a common metabolic disorder that a one of the important factors in the etiology is considered to oxidative damage. The present study intends to study the effect of swimming training with Arbutin on total oxidant status (TOS) and total antioxidant status (TAS) in kidney tissue of Alloxan-induced diabetic rats. Methods: We randomly divided 42 male Wistar rats that had an average weight of 195 g to 220 g into 6 groups (7 rats per group) - control, diabetic, arbutin, diabetic-arbutin,  diabetic-swimming  training,  and  diabetic-combinatorial. Swimming training protocol consisted of 5 days/week for 6 weeks at 5-36 min/day. Diabetes was induced with alloxan [90 mg/kg, intraperitoneal (ip)] in the rats. Arbutin (50 mg/kg, subcutaneous) was administered for 5 days/week. The rats were killed 48 hours after the last treatments and kidney TOS and TAS levels were evaluated. One-way analysis of variance was used for data analysis. Results: After six weeks of supplementation with arbutin, swimming  training and the combination of swimming  training  and arbutin, we observed a significant decrease in TOS (P<0.05) and elevated TAS (P<0.05) levels in the alloxan-induced diabetic rats.  Conclusion: The combined effect of swimming training and arbutin supplementation can play a major role against renal oxidative stress by modulating total oxidant and antioxidant status in alloxan-induced diabetic rats.

Combined Effect of Swimming Training and Arbutin Supplementation on Kidney Total Oxidant and Antioxidant Status in Alloxan-induced Diabetic Rats Keywords:

Diabetes , Arbutin , TOS , TAS , Swimming training , تمرین شنا , آربوتین , وضعیت اکسیدانی تام , وضعیت آنتی اکسیدانی تام , دیابت