Numerical study of heat transfer inside agar jell for different nanoparticles infusion rateBy means of magnetic field

In magnetic fluid hyperthermia therapy, controlling temperature elevation and optimizing heat generation is an immense challenge in practice. The resultant heating configuration by magnetic fluid in the tumor is closely related to the dispersion of particles, frequency and power of magnetic field, and biological tissue properties. In this study, by using experimental results of nanoparticles distribution inside Agarose gel according to various injection velocity, 4μL /min ,10μL /min , 20μL /min , and 40μL /min , for 0.3cc magnetite fluid, power dissipation inside gel has been calculated and used for temperature prediction inside of the gel. To solve bio-heat transfer equation, we used a finite element method and for verifying our model, an exponential heat generation function has been used. To show the accuracy of the model, simulations have been compared with numerical and experimental results, reported in literature. Outcomes demonstrated that by increasing the flow rate injection at determined concentrations, mean temperature drops.

Keywords:

hyperthermia , bio-heat transfer equation , magnetic fluid , nanoparticles distribution , powerdissipation