Is Basal-like Carcinoma of the Breast a Distinct Clinicopathologic Entity? A Critical Review with Cautionary Notes
Publish place: IRANIAN JOURNAL of PATHOLOGY، Vol: 2، Issue: 4
Publish Year: 1386
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJP-2-4_010
تاریخ نمایه سازی: 5 آبان 1393
Abstract:
This review deals with studies that have used cDNA microarrays and immunohistochemistry to identify a subtype of breast carcinoma recently known as basal-like carcinoma. The keybreast carcinoma studies are critically discussed to highlight methodological problems in cohort selection, definitions, interpretation of results, and statistical analysis. It concludes that basal-like carcinomas do not reflect a single, biologically uniform group of breast cancers and show significantvariations in their phenotypes, grades, immunoprofiles, and clinical behavior, just as a wide rangeof subtypes and behaviors is observed among epithelial/luminal-derived breast carcinomas. Welldesigned studies with comparison of low grade non-basal versus low grade basal and high grade non-basal versus high grade basal carcinomas are necessary before one can be convinced that this subtype represents a distinct clinicopathologic entity.
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Authors
Farid Moinfar
Unit of Breast and Gynecologic Pathology, Department of Pathology, Medical University of Graz, Austria