Giant Cell Glioblastoma - A Rare Pediatric Cerebral Neoplasm
Publish place: IRANIAN JOURNAL of PATHOLOGY، Vol: 6، Issue: 3
Publish Year: 1390
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJP-6-3_007
تاریخ نمایه سازی: 5 آبان 1393
Abstract:
Giant cell glioblastoma is an extremely rare variant of Glioblastoma (WHO grade IV) which is characterized by a predominance of bizarre, multinucleated giant cells. These tumors comprise of 0.8%of brain tumors and up to 5% of glioblastomas. In pediatric age group, these tumors are still uncommonwith only around 53 published cases since 1952. Here, we report a case of a 12- year old female patient who presented in outpatient clinic with a short period history of headache and seizures.A CT scan showed a large right sided frontal space occupying lesion with areas of calcification. Thepatient was operated and subsequent histopathology revealed a high-grade astrocytic tumor with increased cellularity, atypical mitosis, bizarre multinucleated giant cells along with large areas of ischemic necrosis and calcification. A diagnosis of Giant cell glioblastoma (WHO Grade IV) was made. The patient was symptomatically well at 3-month follow-up.
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Authors
Indranil Chakrabarti
Dept. of Pathology, North Bengal Medical College, Siliguri, India
Nilanjana Ghosh
Dept. of Community Medicine, North Bengal Medical College, Siliguri, India